ADVANCED FUNCTIONAL MRI EQUIPMENT FOR 3 TESLA SYSTEM: SCHIZOPHRENIA

该子项目是利用由NIH/NCRR资助的共享仪器赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。列出的机构是用于资助的，不一定是研究者的机构。描述（由申请人提供）：来自巴尔的摩的马里兰州大学校园的研究人员要求资助购买先进的功能性磁共振成像硬件和软件，以增强3.0特斯拉研究专用磁铁。这个新收购的研究磁铁的能力仅限于其主要项目，即扫描膝盖作为多中心骨关节炎倡议的一部分。虽然扫描仪本身是最先进的设备，其相关的工具是非常有限的，不会促进磁共振研究在这个校园的增长。此外，即使在完成其产生膝关节的结构图像的主要目标之后，扫描仪在大部分时间内也是空闲的。这种扫描仪缺乏合适的硬件和软件，严重限制了这种高场磁体在研究中的使用。目前使用磁共振成像的NIH赞助研究人员来自校园内的各个部门，包括放射学，神经病学，精神病学，药理学，心脏病学，解剖学和生理学。这些研究人员在有限的时间内使用马里兰州大学医疗系统操作的临床1.5特斯拉扫描仪进行研究。在过去的几年里，由于临床需求的不断增长，医院扫描仪用于研究的时间变得越来越困难。这种限制性的情况导致一些研究人员将他们的研究转移到邻近的机构。医院扫描仪上没有时间给新的调查人员。新的研究专用的3.0特斯拉机器有望通过加强当前研究人员的研究，并增加新研究人员对急需的MR仪器的使用，来改变生物医学磁共振的这种情况。拟议中的仪器升级有望通过使用功能磁共振成像、扩散张量成像和光谱学等技术来推进人类大脑功能领域的研究。与优化线圈并行成像结合进行此类研究的能力将使位于巴尔的摩的马里兰州大学的磁共振研究社区处于功能性神经成像研究的最前沿。

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): Researchers from across the campus of University of Maryland, Baltimore request funding for the purchase of Advanced Functional MRI hardware and software to enhance a 3.0 Tesla research-dedicated magnet. This newly-acquired research magnet has capabilities limited to its primary project, which is to scan knees as part of a multi-center Osteoarthritis initiative. While the scanner itself is state of the art equipment, its associated tools are very limited, and will not foster the growth of magnetic resonance research on this campus. Additionally, the scanner is idle for the most part even after fulfilling its primary objective of producing structural images of the knee joints. The lack of suitable hardware and software on this scanner has severely limited the use of this high field magnet for research. NIH sponsored investigators who are currently using magnetic resonance imaging come from various departments within the campus including radiology, neurology, psychiatry, pharmacology, cardiology, anatomy and physiology. These researchers use the clinical 1.5 Tesla scanners operated by the University of Maryland Medical System during limited hours to conduct their research. Availability of hospital scanner time for research has become increasingly difficult over the past few years due to growing clinical demand. This restrictive situation has led some of the investigators to move their research to neighboring institutions. No time is available on the hospital scanner for new investigators. The new research-dedicated 3.0 Tesla machine promises to change this situation for biomedical magnetic resonance by enhancing the research of current investigators, and increasing access to much needed MR instrumentation for new investigators. The proposed upgrade to the instrument promises to advance research in the area of human brain function through use of techniques such as fMRI, diffusion tensor imaging, and spectroscopy. The capability of performing such research in conjunction with parallel imaging with optimized coils will allow the magnetic resonance research community at the University of Maryland, Baltimore to be at the forefront of functional neuroimaging research.