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Macaque studies of correlates of HIV protection

Macaque studies of correlates of HIV protection
HIV 保护相关性的猕猴研究
批准号：
7174910
负责人：
John R Mascola
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7174910
关键词：
AIDS education /preventionAIDS vaccinesMacaca mulattaantiviral antibodycellular immunitycytotoxic T lymphocyteenzyme linked immunosorbent assayhuman immunodeficiency virus 1human tissuehumoral immunityimmunomodulatorsinterleukin 2neutralizing antibodynonhuman therapy evaluationpassive immunizationvaccine developmentvaccine evaluationvector vaccine

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中文摘要
翻译
目前的HIV候选疫苗引起相当有效的细胞免疫应答，但仅产生低水平的中和抗体。这种基于CTL的疫苗（例如，基于DNA免疫的疫苗）不能预防感染，但对疾病进程有有益的影响。相反，被动输注的抗体可以提供完全保护，但必须以导致血清抗体水平远高于当前免疫策略产生的剂量施用。我们正在研究被动转移的中和抗体单独或与疫苗接种诱导的主动细胞免疫相结合的效果。
英文摘要
Current HIV vaccine candidates elicit reasonably potent cellular immune responses, but only low levels of neutralizing antibodies. Such CTL based vaccines (e.g., those based on DNA immunization) do not prevent infection, but can have a beneficial effect on disease course. In contrast, passively infused antibodies can provide complete protection, but must be administered in doses that result in serum antibody levels much higher than can be generated by current immunization strategies. We are studying the effect of passively transferred neutralizing antibodies alone, or in combination with active cellular immunity inducted by vaccination.
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会议论文
PASSIVE ANTIBODY PROTECTION IN SHIV CHALLENGE MODEL
PASSIVE ANTIBODY PROTECTION IN SHIV CHALLENGE MODEL
PASSIVE ANTIBODY PROTECTION IN SHIV CHALLENGE MODEL
Immunogenicity Studies of HIV-1 immunogens
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