Genetic analysis of migraine and comorbid psychiatric disorders using twin families

典型的偏头痛是一种常见的，使人衰弱和痛苦的疾病，通常影响人们在他们最具生产力的年份（西方人群中高达25%的女性和7.5%的男性）。此外，一些研究已经证明了社区样本中精神疾病（即焦虑和抑郁）与偏头痛之间的横截面关系。世界卫生组织（世卫组织）最近将偏头痛和严重抑郁症列为世界上20大主要残疾原因之一，其影响远远超出了受苦的个人，影响到家庭和社区。在所有年龄段的男性和女性中，抑郁症和偏头痛是影响寿命的第1和第19大残疾原因。虽然偏头痛和抑郁症在我们的社会中非常普遍，但它们的病因仍然相对模糊，并且没有基于实验室的诊断测试来识别患有这些疾病的人。由于对它们知之甚少，定位克隆方法是确定这些疾病背后的分子机制的唯一可行方法。该项目将收集具有足够功效的样本以进行全基因组连锁筛选，以i）鉴定新的易感基因，和ii）确认先前报道的偏头痛和共发精神疾病的易感基因。在该样本中鉴定（并确认）的易感基因将为进一步阐明偏头痛（和共同发生的精神疾病）的复杂分子途径提供线索，并最终有助于诊断测试和合理治疗策略的发展。

Typical migraine, is a frequent, debilitating and painful disorder that normally affects people during their most productive years (up to 25% of females and 7.5% of males in Western populations). Additionally, several studies have demonstrated a cross-sectional relation between psychiatric disorders (namely anxiety and depression) and migraine in community samples. The World Health Organization (WHO) recently identified migraine and major depression among the world's top 20 leading causes of disability, with an impact that extends far past the suffering individual, to the family and community. In both sexes of all ages, depression and migraine are the 1st and 19th leading causes of disability affected life years. Although both migraine and depression are highly prevalent in our society, their aetiologies remain relatively obscure and there are no laboratory based diagnostic tests that identify those who suffer from the disorders. Because so little is known about them, a positional cloning approach is the only feasible way to identify the molecular mechanisms underlying these disorders. This project will collect a sample with sufficient power to perform a genome wide linkage screen to i) identify novel susceptibility genes, and ii) confirm previously reported susceptibility genes for migraine and co-occurring psychiatric disorders. The susceptibility genes identified (and confirmed) in this sample will provide clues to the further elucidation of the complex molecular pathways of migraine (and co-occurring psychiatric disorders) and, finally, will help in the development of diagnostic tests and rational treatment strategies.