Modeling of Protein Interactions 2007

描述（由申请人提供）：要求支持将于2007年9月30日至10月2日在堪萨斯州劳伦斯举行的2007年蛋白质相互作用建模多学科会议（MPI2007）。会议将包括生物、物理和计算科学家，并将重点讨论确定蛋白质复合物的挑战和现有方法，包括实验研究、基于知识的方法、序列分析和结构方法。MPI2007的主要目标将是批判性地探索工具的可用性，以提高蛋白质相互作用信息的可靠性，重点是广泛定义的基于模板的蛋白质-蛋白质相互作用建模。由于分析是基于蛋白质的结构，并结合了额外的信息，试图有助于理解它们在细胞中的作用，蛋白质相互作用的大规模重建将建立在蛋白质结构倡议的结果之上。我们将讨论的一些基本问题如下。蛋白质对接会以类似于结构预测的方式进化吗？换句话说，基于知识的方法是否能提供最有用的信息，是否有足够的蛋白质-蛋白质模板？类似于PSI的大规模协同努力来确定蛋白质-蛋白质模板，至少在原则上有意义吗？这个领域是否足够成熟，能够应对这样的挑战？预测工具如何与多种实验技术（如质谱、低温电子显微镜、交联、核磁共振等）相结合以提高可靠性？

DESCRIPTION (provided by applicant): Support is requested for the multidisciplinary conference Modeling of Protein Interactions 2007 (MPI2007) to be held September 30 - October 2, 2007 in Lawrence, Kansas. The meeting will involve a combination of biological, physical, and computational scientists, and will focus on challenges and available methodologies in the determination of protein complexes, including experimental studies, knowledge-based methods, sequence analysis, and structural approaches. The primary goal of MPI2007 will be to critically explore the availability of tools for improving the reliability of protein interaction information, focusing on broadly defined template-based modeling of protein-protein interactions. Since the analysis is based on the structures of proteins and incorporating additional information attempts to contribute to the understanding of their cellular roles, a large scale reconstruction of protein interactions will build on the results of the Protein Structure Initiative. Some of the fundamental questions we will discuss are as follows. Will protein docking evolve in a way similar to structure prediction? In other words, will knowledge-based methods provide the most useful information, and will be there enough protein-protein templates? Does a large-scale concerted effort to determine protein-protein templates, similar to PSI, make sense, at least in principle? Is the field mature enough to meet such a challenge? How can prediction tools be combined with a diverse set of experimental techniques (e.g., mass spectroscopy, cryoelectron microscopy, cross-linking, NMR, etc) to improve reliability? Experts from various areas of protein interactions were selected to serve on the Advisory Committee and to present at the conference. Further presentations will be selected by the Advisory Committee to cover all major methodologies of protein complex determination and modeling. A growing number of highly qualified women are working in the areas covered by the conference and the female speakers will be represented in each section. A poster session will be held on one of the conference days. The conference will be relatively small - approximately 100 participants. The organizers will pay special attention to attracting young investigators as speakers and poster presenters. Participation of students and postdoctoral fellows will be encouraged. Efforts will be made to diversify the participation by attracting minority scientists and graduate students by contacting faculty members working in the areas of Biophysics and Biochemistry in minority-serving institutions. The concept of the cell as a collection of multisubunit protein machines that determine its behavior in normal and diseased states is emerging as a cornerstone of modern biology. The planned Modeling of Protein Interactions 2007 (MPI2007) meeting will involve a combination of biological, physical, and computational scientists, and will focus on challenges and available methodologies in the determination of protein complexes, including experimental studies, knowledge-based methods, sequence analysis, and structural approaches.