Summit on Systems Biology: Integrating Basic and Clinical Research

描述(由申请人提供)： 尽管还原实验将继续是#年生物医学研究的支柱 从近期来看，系统生物学方法代表着未来科学的先锋。 有效使用基于系统的方法可以在更大的层次结构中识别上下文 实验结果，并揭示还原实验者所隐藏的关系。 这次会议的目的是吸引带头的科学先锋申请 系统地解决生物和生物医学问题，并提供一个有效的论坛 将这些战略更广泛地传播给生物医学研究界。决赛 这次会议的一天将包括介绍计算和 将相关工具提供给感兴趣的调查人员。具体而言，会议的目标是： 1.将系统方法应用于基础生物医学的领先者聚集在一起 与临床和转化研究中的那些人一起进行研究，以继续对话和 相互学习是在2006年第一次首脑会议上发起的。 2.让这些领先的科学家和政策制定者参与关于 生物和生物医学研究的系统方法和最快速的 实施系统方法在医学中的应用的方法。 3.对所应用的系统方法的技术进行深入说明 到细胞和亚细胞分析。 4.为临床科学家提供深入的系统应用启蒙 翻译和临床研究中的方法。 5.在以下方面提供系统方法应用方面的实践和培训 基础、临床和转化性研究。 最后，由于疾病很少涉及单一系统，诊断和治疗将是 通过大量数据集的集成显著增强；即，通过应用集成的 系统方法。因此，本次会议的最终广泛目的是使最近的 基础生物学研究中的系统方法向临床和翻译的进展 研究受众，促进智力交流。

DESCRIPTION (provided by applicant): Although reductive experimentation will continue to be the mainstay of biomedical research in the near term, the systems biology approach represents the vanguard of science for the future. Effective use of a systems-based approach can identify context within a greater hierarchy of experimental results and reveal relationships that are hidden to the reductive experimentalist. The purpose of this meeting is to attract that scientific vanguard leading the charge to apply systems approaches to biological and biomedical problems, and to provide an effective forum for broader dissemination of these strategies to the biomedical research community. The final day of this conference will consist of "hands on" workshops to introduce computational and related tools to interested investigators. Specifically, the conference aims: 1. To bring together the leaders in applying systems approaches to basic biomedical research with those in clinical and translational research to continue the dialogue and mutual learning initiated in the first Summit in 2006. 2. To engage these leading scientists and policymakers in a discussion on the value of a systems approach to biological and biomedical research and on the most expeditious means of implementing the application of the systems approach in medicine. 3. To provide an in depth description of the technologies of systems approaches as applied to cellular and sub-cellular analyses. 4. To provide an in depth initiation of the clinical scientist into the application of systems approaches in translational and clinical research. 5. To provide hands on exposure and training in the applications of systems approaches in basic, clinical and translational research. Finally, since disease rarely involves a single system, diagnosis and treatment would be significantly enhanced by integration of extensive data sets; i.e., by applying an integrated systems approach. The final broad purpose of this conference is, therefore, to bring the recent advances in systems approaches in basic biological research to a clinical and translational research audience and to facilitate the intellectual exchange.