Genome-wide epigenetic analysis of Childhood Acute Lymphoblastic Leukaemia

在所有儿童癌症中，急性淋巴细胞白血病是最常见的。迄今为止，儿童白血病的病因机制仍不清楚。尽管5年无事件生存率相对较高（高达80%），但仍不清楚为什么预期预后良好的儿童会死于该疾病。因此，仍有必要进一步完善目前的诊断和预后参数，这些参数将共同改善白血病儿童的预后。

Of all cancers in children, Acute Lymphoblastic Leukaemia is the most common. To date, the causal mechanism(s) for leukaemia in children remain unclear. Although 5-year event-free survival rates are relatively high (up to 80%) it is still unclear why children expected to survive with a good prognosis, succumb to the disease. Therefore, there is still a need to further refine current diagnosis and prognosis parameters that will together lead to improved outcomes to children with leukaemia.