Kidney Multiphoton Analysis of Therapeutic Agents

描述（由申请方提供）：INphoton，LLC的综合科学团队将开发活体多光子显微镜测定的标准操作规程，用于定量活体大鼠肾脏内的荧光药物递送、细胞摄取、细胞内分布、代谢和生理/治疗效应。商业应用需要对一些现有的测定方法进行改进。由此产生的产品将使INphoton能够将商业服务扩展到制药和生物技术公司，以加强对潜在产品的临床前评估。INphoton，LLC将商业化多光子显微镜用于肾脏临床前药物评价。这将极大地帮助评估潜在治疗剂的细胞位置、功能作用和不良影响。由于这是不可能与其他成像模式，这种方法补充和扩展现有的成像技术。

DESCRIPTION (provided by applicant): The integrated scientific team of INphoton, LLC will develop standard operating procedures for intravital multiphoton microscopy assays quantifying fluorescent drug delivery, cellular uptake, intracellular distribution, metabolism, and physiologic/therapeutic effects within the kidney of live rats. Refinement of some existing assays will be necessary for commercial utilization. The resulting products will enable INphoton to extend commercial services to pharmaceutical and biotech companies to enhance preclinical evaluation of potential products. INphoton, LLC will commercialize multiphoton microscopy for preclinical drug evaluation in the kidney. This will greatly aid evaluation of a potential therapeutic agent's cellular location, functional effects and adverse affects. Since this is not possible with other imaging modalities, this approach complements and extends existing imaging technologies.