Biodefense Training in Host-Pathogen Interactions

描述（由申请人提供）：这个新的提案，生物防御培训在主机病原体相互作用，旨在作为一个种子项目，研究生在致病微生物的研究，建立人类或动物感染的机制，以及发现新的疗法或对策，防止人类疾病的严格科学教育。该提案借鉴了芝加哥大学微生物学和免疫学委员会教师的科学优势，以及通过最近成立的五大湖生物防御和新兴传染病卓越区域中心提供的基础设施，核心结构中的资源允许通过最先进的显微镜，质谱，免疫学，动物感染和基因组学设施研究病原体。芝加哥大学的结构承诺允许在BSL-2和BSL-3实验室中开展宿主-病原体相互作用的工作，这些实验室专门为CDC A-C类选择因子以及阿贡国家实验室的里基茨区域生物防护实验室设计，阿贡国家实验室是由芝加哥大学为国家过敏和传染病研究所建造和运营的联邦实验室。芝加哥大学教师对生物防御和宿主病原体研究的研究和培训卓越的承诺反映在最近成立的微生物学系。 在未来五年内任命七名新教师的扩张性增长伴随着最近微生物学研究生培训的扩大以及教师和研究生在这一领域已经取得的优异成就。16个培训教师研究细菌致病机理，动物病毒，病毒生理学和致病机理，植物致病机理，耐药微生物，微生物毒素和对感染的免疫反应。学员是从150名申请人中挑选出来的，这些申请人具有学士学位，平均GRE和GPA成绩分别为1375+5（81%）和3.3。 我们的培训计划的最终目标是雄心勃勃的，旨在建立一个一流的研究计划，在生物防御和宿主-病原体相互作用。

DESCRIPTION (provided by applicant): This new proposal, Biodefense Training in Host-Pathogen Interactions, is intended as a seed project for rigorous scientific education of graduate students in the study of pathogenic microbes, their mechanisms of establishing human or animal infections, as well as the discovery of novel therapies or countermeasures that prevent human disease. The proposal draws on scientific strengths of University of Chicago faculty in the Committees on Microbiology and Immunology as well as on infrastructure provided through the recently established Great Lakes Regional Center of Excellence in Biodefense & Emerging Infectious Diseases, with resources in core structures that permit the study of pathogens via state of the art microscopy, mass spectrometry, immunology, animal infection and genomics facilities. Infrastructural commitments at the University of Chicago permit work on host-pathogen interactions in BSL-2 and BSL-3 laboratories, specifically designed for CDC select agents of categories A-C as well as on the Ricketts Regional Biocontainment Laboratory at Argonne National Laboratory, a federal laboratory that is constructed and operated by the University of Chicago for the National Institute of Allergy and Infectious Diseases. The commitment of University of Chicago faculty towards research and training excellence in biodefense and host-pathogen research is reflected in the recent establishment of the Department of Microbiology. Expansive growth with the appointment of seven new faculty over the next five years is accompanied by the recent expansion of graduate training in Microbiology and by the already excellent achievements of faculty and graduate students in this area. Sixteen training faculty study bacterial pathogenesis, animal viruses, viral physiology and pathogenesis, plant pathogenesis, drug resistant microbes, microbial toxins and the immune response to infections. Trainees are selected from a pool of 150 applicants with Bachelor's degree and average GRE and GPA scores of 1375+5 (81%) and 3.3 respectively. The ultimate goals of our training program are ambitious and aim at establishing a premier research program in biodefense and host-pathogen interactions.