NRSA Institutional Training Program in Oral Biology

描述(由申请者提供)：为响应NIDCR对机构培训计划的呼吁，以培养能够应对牙科、口腔和颅面研究的机会和挑战的熟练和多才多艺的科学家，建议设立口腔生物学T32 NRSA机构培训补助金。这项提案是佛罗里达大学口腔生物学T32培训助学金的延续。这一基础广泛的口腔生物学基础和临床生物医学调查培训计划将有助于满足对基础、多学科生物医学口腔健康研究的持续需求，并弥补临床医生/科学家和翻译、面向患者的口腔和颅面研究人员的严重短缺。资金充足的基础和临床研究人员已经聚集在一起，提供与口腔健康问题相关的生物医学科学方面的各种培训机会。研究培训的重点将是口腔细菌和真菌传染病、宿主寄生虫相互作用、疫苗策略、相关自身免疫性疾病、结缔组织生物学、基因治疗和牙科/颅面临床研究。这项建议的具体目标是：1)培养基本的多学科生物医学科学家，从事口腔健康问题的研究；2)培养以患者为导向的牙科临床科学家；3)培养具有博士学位和牙科专业培训的临床医生科学家；4)提供临床调查培训，以培养牙科临床和翻译研究人员；以及5)为牙科学生和牙科教职员工提供临床研究和基础牙科和颅面研究的短期经验，以提高他们作为临床医生科学家的兴趣和成功。将利用牙科和医学学院的跨学科研究培训计划。研究培训资源包括生物医学科学博士跨学科计划、临床调查高级专业计划、综合临床研究中心以及资金雄厚的基础和临床生物医学科学家。通过使用这些资源和其他资源的组合，提供了一个综合和灵活的培训计划，将满足各种受训人员的需求，并具有最大的潜力培养出一支能够成功地设计和测试新知识的“高技能和互动科学家队伍”，以促进口腔和头面部结构疾病和异常的检测、治疗、预防和治愈。关联性。口腔疾病是人类中传播最广泛的疾病之一。它们会导致严重的身体和心理不适，经济困难，并对一个人的整体健康产生负面影响。需要继续进行研究，以发现、治疗和预防口腔疾病，以改善人类人口的福祉。这笔培训赠款将培养基础和临床科学家，他们将开发和实施新的方法，以改善世界范围内的口腔健康。

DESCRIPTION (provided by applicant): In response to the NIDCR's call for institutional training programs to produce skilled and versatile scientists who can address the opportunities and challenges in dental, oral and craniofacial research a Comprehensive T32 NRSA Institutional Training Grant in Oral Biology is proposed. The proposal is a continuation of a T32 Training Grant in Oral Biology at the University of Florida. This broad based training program in basic and clinical biomedical investigations in oral biology will help to satisfy the continuing need for basic, multidisciplinary biomedical oral health research and to remedy the serious shortage of clinician/scientist and translational, patient oriented oral and craniofacial researchers. A combination of well funded, basic and clinical researchers have been brought together to provide a variety of training opportunities in biomedical sciences relevant to issues in oral health. The focus of the research training will be in oral bacterial and mycotic infectious diseases, host parasite interactions, vaccine strategies, relevant autoimmune diseases, connective tissue biology, gene therapy, and dental/craniofacial clinical research. The specific aims of this proposal are: 1) to produce basic multidisciplinary biomedical scientists to do research on issues of oral health; 2) to produce patient oriented dental clinician scientists; 3) to produce clinician scientists with a PhD and dental specialty training; 4) to provide clinical investigation training to produce dental clinical and translation researchers; and 5) to provide short-term experiences for dental students and dental faculty in clinical investigation and basic dental and craniofacial research to promote their interest and success in careers as clinician scientists. Interdisciplinary research training programs in the Colleges of Dentistry and Medicine will be utilized. Research training resources include the PhD Interdisciplinary Program in Biomedical Sciences, an Advanced Professional Program in Clinical Investigation, the General Clinical Research Center and well funded basic and clinical biomedical scientists. By using combinations of these and other resources, an integrated and flexible training program is offered that will meet the needs of a variety of trainees and have maximum potential to produce a "cadre of highly skilled and interactive scientists" who can successfully devise and test new knowledge to advance the detection, treatment, prevention and cure of diseases and abnormalities of the oral and craniofacial structures. Relevance. Oral diseases are some of the most wide spread diseases in the human population. They can result in severe physical and psychological discomfort, financial hardship, and negatively affect a person's general health. Continued research is needed to detect, treat and prevent oral diseases to improve the well being of the human population. This training grant will produce basic and clinical scientists who will develop and implement new methods to improve oral health World-wide.