Clinical Trial Network: Southwest Node

新墨西哥州酒精中毒，药物滥用和成瘾中心（CASAA）的大学提交了一份 NIDA临床试验网络（CTN）西南节点的更新申请。在最初的资金 在此期间，西南节点为研究活动做出了实质性和具有成本效益的贡献 的CTN。该节点已成功地完成了五个协议，以及一个单一的网站适应 这些协议（求职者研讨会，协议0020）在治疗计划的土著美国人。 除参与议定书外，联络点还在议定书领域作出了重要贡献 发展、培训和委员会工作。在最新的节点性能指标中， CCTN（2005年8月至2006年7月），西南节点得分或高于全国平均水平的所有6个 与试验性能相关的节点性能指标。节点做出了杰出的贡献 推进少数民族和其他服务不足人群的成瘾治疗临床科学， 在CTN协议中贡献了所有西班牙裔参与者的17%，以及所有美洲原住民参与者的54%， 包括102名参加方案0020改编的美国原住民。西南节点还 我们一直非常积极地将基于CTN的治疗方法推广到实践中，我们所有的CTPs都已经 采用了一种或多种新的循证治疗方法。西南节点的特殊优势包括： 1)行为治疗和药物治疗的临床试验的良好记录; 2)在开发和评估成瘾创新疗法方面的长期经验; 3)具有挑战性人群的丰富经验，包括共病，无家可归者， 4）在传播和培训研究方面的专门知识; 5）高 节点CTP中少数族裔患者的集中度（70%）;以及6）边境的地理代表性 西南为了说明可以从西南节点发起的CTN范围内的研究， 描述了一个概念，提出了一项使用药物治疗可卡因依赖的双硫仑务实试验 管理模式相关性：这项工作支持CTN的使命，以改善药物滥用治疗， 美国使用科学方法对药物滥用进行严格的多地点试验 在现实世界中的治疗干预措施，并促进循证做法的传播。

The University of New Mexico Center on Alcoholism, Substance Abuse, and Addictions (CASAA) submits an application for renewal of the Southwest Node of the NIDA Clinical Trials Network (CTN). In its initial funding period, the Southwest Node has made a substantial and cost-effective contribution to the research activities of the CTN. The Node has successfully completed five protocols, as well as a single-site adaptation of one of these protocols (Job Seekers Workshop, protocol 0020) at a treatment program for Native Americans. Beyond participation in protocols, the Node has made important contributions in the areas of protocol development, training, and committee work. In the most recent Node performance measures available from the CCTN (August 2005-July 2006), the Southwest Node scored at or above national average on all 6 of the Node performance measures relating to trial performance. The Node has made an outstanding contribution to advancing the clinical science of addictions treatment in minority and other underserved populations, contributing 17% of all Hispanic participants in CTN protocols, and 54% of all Native American participants, including 102 Native Americans enrolled in the adaptation of protocol 0020. The Southwest Node has also been highly active in disseminating CTN-based treatments into practice, and all of our CTPs have already adopted one or more new evidence-based treatments. Particular strengths of the Southwest Node include: 1) a well-established track record of clinical trials for both behavioral treatments and pharmacotherapies; 2) longstanding experience in the development and evaluation of innovative treatments for addictions; 3) substantial experience with challenging populations including co-occurring disorders, the homeless, runaway adolescents, and pregnant women; 4) expertise in research on dissemination and training; 5) a high concentration (70%) of minority patients in the Node CTPs; and 6) geographic representation of the border Southwest. To illustrate CTN-wide research that could be initiated from the Southwest Node, a protocol concept is described proposing a pragmatic trial of disulfiram for cocaine dependence using a medication management model. Relevance: This work supports the CTN's mission to improve drug abuse treatment in the United States using the methods of science to conduct rigorous multi-site trials of substance abuse treatment interventions in real-world settings, and to facilitate the dissemination of evidence-based practices.