Vector Production Core

疫苗生产核心的工作包括在三个相互关联的领域开展工作：活疫苗， 重组载体开发;新型佐剂开发;和蛋白质生产。将描述CHAVI小组在载体和佐剂开发方面所做的努力。将描述追求每种技术的理由，迄今为止在开发该技术方面所完成的工作，以及进一步开发该技术的近期计划。该CHAVI小组将开始推进这些技术中最有前途的进入人体临床试验，最早在资助期的第二年。该核心的蛋白质生产组件将服务于Haynes RO 1、Shaw SLG 项目，Sodroski SLG项目和结构生物学核心D。具体而言，我们将在以下几个方面开展工作： 1.活重组载体开发 a.重组嵌合腺病毒 B.重组分枝杆菌 C.重组体水瘤性口炎病毒 2.新型佐剂开发 a.聚合物 B.趋化细胞因子 C. TLR激动剂 3.重组蛋白生产

The work of the Vaccine Production Core encompasses efforts in three inter-related areas: live, recombinant vector development; novel adjuvant development; and protein production. The efforts that will be pursued in vector and adjuvant development by this CHAVI group will be described. A rationale for pursuing each technology, the work accomplished to date in developing that technology, and the immediate plans for further development of that technology will be described. This CHAVI group will begin to advance the most promising of these technologies into human clinical testing as early as the second year of the funding period. The protein production component of this core will serve the Haynes RO1, the Shaw SLG project, the Sodroski SLG project, and the Structural Biology Core D. Specifically, we will pursue work in the following areas: 1. Live, recombinant vector development a. Recombinant chimeric adenovirus b. Recombinant mycobacteria c. Recombinant vesicular stomatitis virus 2. Novel adjuvant development a. Polymers b. Chemoattractant cytokines c. TLR agonists 3. Recombinant protein production