Cold Spring Harbor 72nd Symposiumon Quantitative Biology: Clocks & Rhythms

描述（申请人提供）：冷泉港定量生物学研讨会每年6月初在纽约冷泉港冷泉港实验室举行。他们汇集了来自世界各地的大约300-400名科学家，展示和评估快速发展的生物研究领域的新数据和想法。每年都会选择一个似乎处于需要全面和深入审查和审查阶段的主题。研讨会一直寻求来自美国和其他国家的研究工作者，以确保项目的广泛性和深度，并充分利用他们的具体贡献。他们还寻求为优秀的年轻科学家（包括研究生和博士后）提供参与和与更资深的科学家交流的机会。研讨会还寻求妇女和少数族裔科学家的参与。研讨会汇集了使用各种方法的科学家，例如遗传学，生物化学，分子生物学，细胞生物学和结构研究，来分析讨论领域的问题。Leading Strand档案馆将会议的视频记录立即提供给与会者的同事，而研讨会的会议记录则由实验室出版，从而提供给比参加会议的科学家更广泛的受众。在研讨会期间对主要科学家进行的深入访谈提供了当前研究状况的另一种快照。将继续计划年度专题讨论会，以进一步推动生物医学科学的进步。本提案要求支持第72届冷泉港研讨会，该研讨会将以“时钟与节奏”为主题。会议将讨论生物钟现象及其在各种细胞、组织和生物体中的功能和功能障碍。所有生物体内都有生物钟来记录时间，尤其是正常一天的暗-光循环。在过去的半个世纪里，这些时钟的分子基础一直是深入研究的焦点。生物节律依赖于生物钟，反过来又受睡眠和清醒、饮食、代谢率和体温的影响和调节。这些节律的紊乱不仅会影响睡眠模式，还会导致抑郁症和相关疾病。2007年冷泉港研讨会将汇集该领域的主要专家，讨论他们的最新发现。

DESCRIPTION (provided by applicant): The Cold Spring Harbor Symposia on Quantitative Biology are held yearly at the beginning of June at the Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. They bring together approximately 300-400 scientists from all over the world to present and evaluate new data and ideas in rapidly moving areas of biological research. Each year, a topic is chosen that seems to be at a stage where general and intensive scrutiny and review is needed. The Symposia always seek to bring research workers from the U.S., as well as from broad, so as to ensure the wide scope and depth of the program and to take advantage of their specific contributions. They also seek to provide outstanding younger scientists, both graduate students and post-doctoral fellows, with an opportunity to participate and communicate with more senior scientists. The Symposia also seek to have participation from women and minority scientists. The Symposia bring together scientists who use a variety of approaches, e.g., genetics, biochemistry, molecular biology, cell biology, and structural studies, to analyze problems in the area under discussion. The Leading Strand archive makes video recordings of the talks immediately available to colleagues of those who attended, while the proceedings of the Symposia are published by the Laboratory and thus made available to a wider audience than the scientists who attend the meeting. In-depth interviews with leading scientists undertaken during the Symposium provide an alternative snapshot of the state of current research. The annual Symposia will continue to be planned to further the progress of advancements in biomedical science. This proposal requests support for the 72nd Cold Spring Harbor Symposium which will focus on "Clocks and Rhythms". The meeting will address the phenomenon of biological clocks and their function and dysfunction in a variety of cells, tissues and organisms. All living organisms have internal body clocks that keep track of time, notably the dark-light cycle of the normal day. The molecular basis of these clocks has been the focus of intensive research over the past half-century. Biological rhythms depend upon the body clock, and in turn influence and are regulated by sleep and wakefulness, diet, metabolic rate, and body temperature. Disruption of these rhythms not only affects sleep patterns but also has been found to cause depression and related illness. The 2007 Cold Spring Harbor Symposium will bring together the leading experts in the field to discuss their latest findings.