Participant Perspectives on Drug Use/HIV Research Ethics

描述(由申请人提供)：研究非法药物使用和相关艾滋病毒风险的调查人员面临着独特的道德挑战。醉酒、长期吸毒或艾滋病毒/艾滋病晚期可能会损害同意能力。参与购买毒品和诊断艾滋病毒/艾滋病的犯罪活动使参与者特别容易违反保密规定，这可能导致刑事起诉、社会污名或失业。购买药物需要资金，或者种族和经济健康差距，可能会增加对参与研究的现金或治疗补偿进行胁迫的可能性。RCT设计的参与者在戒毒期间可能会出现戒断症状，或者在实验性治疗与街头药物相互作用时出现副作用。研究成果的传播可能会进一步污蔑或维持社会对历史上受压迫群体的偏见。通过焦点小组、深度访谈和结构化访谈调查，本研究旨在探索弱势非法吸毒者的倍增给研究伦理实践带来的希望、价值和恐惧。这一合作项目结合了福特汉姆大学道德教育中心的优势和西班牙裔健康理事会以社区为基础的药物滥用和艾滋病毒/艾滋病经验，将深入和深入地审查街头吸毒者对研究风险和收益、知情同意、保密和激励措施的态度，研究流行病学、社会相关性和药物滥用和艾滋病毒相关风险的治疗。此外，还将探讨性别和种族对这些态度的影响。该项目的长期目标是确定经济困难、族裔多样的非法街头吸毒者的道德关切，以反映参与者的价值观和值得信任的方式，为吸毒和艾滋病毒风险研究提供信息并加强这方面的研究。

DESCRIPTION (provided by applicant): Investigators studying illicit drug use and related HIV risk face unique ethical challenges. Intoxication, long term drug use, or advanced stages of HIV/AIDS can impair consent capacity. Involvement in criminal activities to purchase drugs and diagnosis of HIV/AIDS make participants especially vulnerable to breaches in confidentiality that may result in criminal prosecution, social stigmatization, or loss of employment. The need for money to purchase drugs or ethnic and economic health disparities may heighten susceptibility to coercion from cash or treatment compensation for research participation. Participants in RCT designs may suffer withdrawal symptoms during detoxification or side effects when experimental treatments interact with street drugs. Dissemination of research results may further stigmatize or sustain societal prejudices against historically oppressed groups. Through focus groups, in-depth interviews, and structured interview surveys, this research aims to explore the hopes, values, and fears that multiply vulnerable illicit drug users bring to research ethics practices. This collaborative project uniting the strengths of the Fordham University Center for Ethics Education and the community based substance abuse and HIV/AIDS experience of the Hispanic Health Council, will examine in both depth and breath the attitudes of street drug users towards research risks and benefits, informed consent, confidentiality, and use of incentives in research on the epidemiology, social correlates, and treatments for drug abuse and HIV related risks. How gender and ethnicity influence these attitudes will also be examined. Long-term goals of this project are to identify ethical concerns among economically disadvantaged, ethnically diverse illicit street drug users that will inform and enhance drug use and HIV risk research in ways that reflect the values and merit the trust of participants.