Race, Obesity and Enteroinsular Axis in Adolescents

我的职业目标集中在两种并发疾病上，儿童肥胖症和2型糖尿病， 对少数群体青少年的影响显著。确定新的致病机制 解释种族差异以及种族和生活方式因素对预测治疗的潜在影响 结果是我的长期目标。有了这个关注点，我致力于以患者为导向的翻译研究 但我需要获得特定的技能，使我在这一领域更有效率。这个奖项将允许我 通过以下方式实现这些目标。我将：1)加强我的统计和流行病学 基础；2)培养流行病学数据的方法、测量和分析方面的技能；3) 发展预防医学、药物流行病学和生物信息学方面的必要知识 根据我在培训中获得的经验和 )拟议项目的初步结果。在肥胖的非裔美国人(AA)受试者中，我们提出了 升高的GLP-1水平[肠岛轴活动的标记物(EIA)]可以促进脂肪生成和 ：合并症的发展。目前尚不清楚EIA中的这些种族差异是否由 年龄、超重的严重程度、心肺功能(CRF)或自主神经系统的差异 (ANS)调制。我们将评估这三个相互关联的领域(EIA、CRF和ANS调制)。 广泛超重青少年的种族样本。特别是，我们对这一关系感兴趣 EIA活性和胰岛素动力学之间可能的机制途径解释增加 AA青少年肥胖、2型糖尿病(T2 DM)和心血管疾病(CVD)的患病率。 因此，我们将确定EIA、CRF、血糖稳态和高血压危险因素之间的关系。 青少年中的ICVD。这项研究的结果可以转化为医疗实践的变化，可能会有所帮助 尤其是对再生障碍性贫血青少年实施更有效的生理治疗方法。

My career goals are focused upon two concurrent diseases, childhood obesity and type 2 diabetes mellitus, affecting prominently adolescents of minority groups. Identifying new etiopathogenic mechanisms that explain the racial disparity and the potential influence of racial and lifestyle factors on predicting treatment outcomes are my long-term goals. With this focus, I am commited to patient-oriented translational research but I need to acquire specific skills that allow me to be more effective in this area. This award will allow me to accomplish these goals in the following way. I will: 1) enhance my statistical and epidemiological foundation; 2) develop skills in methodology, measurements, and analysis of epidemiological data; 3) develop the neccesary knowledge in preventive medicine, pharmacoepidemiology and bioinformatics necessary for implementing interventional studies based on the experience gained in my training and the )reliminary results of the proposed project. In obese African American (AA) subjects, we have proposed that ncreased GLP-1 levels [marker of enteroinsular axis activity (EIA) ] could promote adipogenesis and the :levelopment of comorbidities. It is still unclear whether these racial differences in EIA are determined by age, severity of overweight, differences in cardiorespiratory fitness (CRF) or autonomic nervous system (ANS) modulation. We will assess these three interrelated areas (EIA, CRF, and ANS modulation) in a bi- racial sample of wide-ranging overweight adolescents. In particular, we are interested in the relation between EIA activity and insulin dynamics as a potential mechanistic pathway to explain the increased prevalence of obesity, type 2 Diabetes Mellitus (T2DM) and Cardiovascular Disease (CVD)in AA youth. ITherefore, we will determine the associations among EIA, CRF, glucose homeostasis, and risk factors for ICVD in adolescents. The results of this study can be translated into medical practice changes and may help to implement a more physiologically effective approach to obesity treatment in AA adolescents, in particular.