CORE 2 DB3: CASPASE-DRIVEN HEMATOPOETIC CELL DIFFERENTIATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 驱动生物学项目3：半胱氨酸天冬氨酸酶驱动的造血细胞分化 淋巴细胞生理学领域的一个新的令人兴奋的发展是发现caspase， 除了它们在介导细胞死亡方面的作用外，它们在T细胞激活中也起着关键和积极的作用 和扩散。一些caspase的激活可以在T细胞激活后的早期检测到，而一些 在没有任何细胞死亡迹象的情况下，caspase底物被切割。半胱氨酸天冬氨酸酶也被展示出来 是激活T细胞所必需的。一种家族性人类免疫缺陷被发现 由caspase-8基因的失活突变引起。总而言之，这些数据使我们能够 提出半胱氨酸氨基转移酶在T淋巴细胞生理学中发挥许可作用的假设 对许多细胞蛋白质进行蛋白质分解处理，这将在该项目中进行测试

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 3: Caspase-driven Hematopoetic Cell Differentiation A new and exciting development in the field of lymphocyte physiology is the finding that caspases, in addition to their role in mediating cell death, also play a critical and positive role in T cell activation and proliferation. Activation of some caspases can be detected early after T cell activation and some caspase substrates are cleaved in the absence of any signs of cell death. Caspases have also been shown to be required for T-cell activation. A familial human immunodeficiency was discovered to be caused by an inactivating mutation in the gene for caspase-8. Taken together, these data allow us to raise the hypothesis that caspases play a permissive role in T lymphocyte physiology presumably by proteolytic processing of a number of cellular proteins, and this will be tested in the project