NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) DATABASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 非酒精性脂肪性肝病（NAFLD）包括从“单纯性脂肪变性”到脂肪变性伴坏死性炎症和不同程度的纤维化（NASH）的一系列肝脏疾病，NASH是一种更严重的疾病形式，在没有大量饮酒的情况下，最终可能导致肝硬化、肝细胞癌和终末期肝病（女性每天<20 gm，男性每天<30 gm）。这是一项多中心、观察性研究，主要旨在创建一个信息数据库，以研究NAFLD的流行病学和自然史。将利用观察期间收集的临床、实验室和组织学数据解决具体假设和问题。本研究将采用前瞻性和回顾性数据收集。将通过患者填写表格和问卷以及对患者进行各种实验室检查和临床程序来进行前瞻性数据收集。将通过审查患者病历和提取各种数据元素进行回顾性数据收集。提取的数据可能包括物理测量和实验室测试结果。专门用于研究目的的程序包括完成研究问卷和抽血以分离血清、血浆和DNA，这些将用于相关的实验室检查并储存用于未来的NAFLD相关研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nonalcoholic Fatty Liver Disease (NAFLD) encompasses the spectrum of liver disorders ranging from "simple steatosis" to steatosis with necroinflammation and varying degrees of fibrosis (NASH), a more serious form of the disease, which can ultimately lead to cirrhosis, hepatocellular carcinoma and end-stage liver disease in the absence of significant alcohol consumption (<20 gm per day in women, <30 gm per day in men). This is a multi-center, observational, study designed primarily to create a database of information for the purpose of studying the epidemiology and natural history of NAFLD. Specific hypotheses and questions will be addressed utilizing clinical, laboratory and histological data collected over the period of observation. Both prospective and retrospective data collection will be utilized for this study. Prospective data collection will be carried out by completion of forms and questionnaires by patients and by performance of various laboratory tests and clinical procedures on patients. Retrospective data collection will be carried out by review of the patient's medical chart and extraction of various data elements. Extracted data may include physical measurements and laboratory test results. Procedures required specifically for research purposes include the completion of study questionnaires and blood draws to isolate serum, plasma and DNA which will be used for pertinent laboratory tests and banked for future NAFLD related studies.