Crystallographic Studies of Chemokines, Chemokine Recept

其中最重要的成就之一是显示出人防御素5(HD5)对乳头状瘤病毒的强烈抑制特性。这些特性使HD5成为预防乳头瘤病毒感染的潜在候选外用药物。另一项成就是鉴定了人β-防御素分子中几个趋化的结构决定因素。在对人β-防御素1突变体的广泛结构和功能研究中，我们首次确定了与趋化因子受体CCR6的结合和激活有关的表位草案。

One of the most significant accomplishments was to show a strong inhibitory properties of human defensin 5 (HD5) against the papillomaviruses. These properties make HD5 a potential candidate for the topical agent in preventing the papillomavirus infection.The other accomplishment was an identification of several structural determinants of chemotaxis in molecules of human beta-defensins. In broad structural and functional studies of mutants of human beta-defensin 1, we characterized (for the first time in case of defensins) a draft of the epitope involved in the binding and activation of the chemokine receptor CCR6.