Translational Neuroscience Research in Alcoholism

描述(由申请人提供)：从基础科学研究中获得的知识在与酒精中毒有关的临床神经科学研究模型的应用方面存在持续的差距。以分子神经科学为基础的新一代精神药理学、神经影像和分子遗传学研究具有广泛的临床意义，这些研究有可能弥合基础研究和临床研究之间的差距。尽管现有科学的质量很高，但在实际弥合这一差距方面的进展也取决于是否有受过适当培训的年轻科学家。这一培训方案的目的是满足这一需求，为总共3000名对酒精中毒领域翻译研究职业感兴趣的医生或博士提供博士后培训。拟议中的培训计划是耶鲁大学医学院精神病学系的一个为期两年的项目，将为博士后实习生提供机会，让他们在职业生涯的初始阶段，几乎全职致力于发展成为酒精中毒翻译研究领域的独立研究人员所需的技能和经验。在这个项目中，有四个核心项目，即临床核心、神经成像核心、遗传学核心和基础科学核心。该计划的教职员工隶属于两个中心拨款(NIAAA资助的酒精中毒转化神经科学中心和退伍军人管理局资助的退伍军人管理局酒精研究中心)，这两个中心都是多学科的，使该小组能够进行快速和双向的研究，从临床前项目(“BASE”)到临床研究(“床边”和“社区”)。申请者将是经过精神病学、内科、临床心理学或神经科学等专业培训的医学博士或博士后候选人。候选人将由录取委员会根据他们在酒精中毒翻译研究领域的卓越潜力来挑选。每年将选出三名申请者参加核心课程：两名申请面向临床的核心项目(临床或神经成像)，一名申请基础科学或遗传学核心项目。该方案包括：(1)个体化研究指导；(2)成功完成转化性研究项目；(3)核心课程，包括药物滥用临床研究和治疗、生物统计学和研究设计研讨会、负责任的科学研究和补助金撰写技能；(4)个别参与系、医学院和大学感兴趣的研讨会；(5)临床培训；(6)教学培训。培训机构包括耶鲁大学医学院精神病学系附属的主要机构。在培训结束时，申请者将非常适合在酒精中毒领域从事翻译研究的独立职业。

DESCRIPTION (provided by applicant): There is a persistent gap in the application of knowledge gained from basic science studies to clinical neuroscience research models related to alcoholism. A new generation of psychopharmacology, neuroimaging, and molecular genetic studies rooted in molecular neuroscience has broad clinical implications and these studies bring the potential to bridge the gap between basic and clinical research. Despite the quality of the available science, progress in actually bridging this gap depends also upon the availability of appropriately trained young scientists. The purpose of this training program is to meet this need by providing post-doctoral training for a total of 3 physicians or PhDs interested in careers in translational research in the field of alcoholism. The proposed training program is a two-year program in the Department of Psychiatry, Yale University School of Medicine, and will afford post-doctoral trainees the opportunity to devote virtually full-time effort during the initial phase of their careers to developing the skills and experience needed to become independent researchers in the field of translational research in alcoholism. Within this program, there are four Core Programs, the Clinical Core, the Neuroimaging Core, the Genetics Core and the Basic Science Core. The program faculty are affiliated with two center grants (the NIAAA-funded Center for the Translational Neuroscience of Alcoholism and the VA-funded VA Alcohol Research Center), both of which are multi-disciplinary and enable the group to conduct research that moves rapidly and in both directions from preclinical projects ("bench") to clinical studies ("bedside" and "community"). Applicants will be MD's or PhD post-doctoral candidates trained in specialties that include psychiatry, internal medicine, clinical psychology or neuroscience. Candidates will be selected by an admission committee based on their potential for excellence in the field of translational research in alcoholism. Three applicants will be selected annually for the Core Components: two for the clinically-oriented core programs (Clinical or Neuroimaging) and one for the Basic Science or Genetics core. The program includes (1) individualized research preceptorship, (2) successful completion of a translational-research project, (3) a core curriculum, which include seminars on substance abuse clinical research and treatment, biostatistics and research design, the responsible conduct of scientific research and grant writing skills and (4) individualized participation in seminars of interest in the Department, Medical School and University, (5) clinical training and (6) training for teaching. The training facilities include the major institutions affiliated with Yale School of Medicine, Department of Psychiatry. At the conclusion of training, applicants will be well suited for independent careers in translational research in the field of alcoholism.