Long-Term Mental Health Consequences of Chornobyl

描述(由申请人提供)： MH51947的这一竞争性更新旨在调查乌克兰基辅一群母亲和儿童的长期福祉，他们于1997年，也就是乔尔诺贝利事故发生11年后首次接受采访。拟议的跟进实地工作将在2004-05年度进行。我们1997年的研究重点是从Chornobyl周围受污染地区疏散到基辅的家庭在85年2月1日至1987年1月31日期间出生的儿童。对照组由性别匹配的同学和他们的母亲组成。1997年的结果显示，与对照组相比，被疏散的母亲报告的孩子有更多的健康问题，有更多的焦虑、抑郁、躯体和创伤后应激症状，并因Chornobyl事故而更关心自己的健康和家人的健康。当时，与同学对照组相比，10-12岁的被疏散儿童的医学评估或自我报告的幸福感几乎没有差异。我们建议扩展我们最初的研究，在儿童大约18岁时，即出现抑郁、焦虑和物质障碍的时候，用CIDI和其他测量方法重新评估队列，并包括体检和血液测试。这一队列是甲状腺癌的最高风险群体，因此成为社会关注的焦点。为了纠正仅有基辅控制的局限性，这项研究将扩大到包括从2002年进行的乌克兰国家共同发病率调查(MH61905)的参与者中挑选的基于人口的控制，这些人与被疏散儿童同龄，生活在未受辐射污染的地区。 原始研究的回复率接近90%，由于样本的居住稳定性，我们预计随访率将好于90%。分析将集中在一组具体的假设上，包括预测两组基辅儿童和母亲在后续行动中将出现更多症状，被疏散的青少年将报告明显更多的躯体和心理症状以及与Chornobyl相关的焦虑，并且与同学对照组相比，他们将有更高的情感、焦虑和物质使用障碍的发生率。我们还预测，基辅控制组的母亲和儿童将比以人口为基础的控制组对Chornobyl更有症状和恐惧。鉴于当前发生的事件，有机会加深我们对应对长期健康威胁的理解是一项关键优势。

DESCRIPTION (provided by applicant): This competing renewal of MH51947 seeks to examine the long-term well-being of a cohort of mothers and children in Kyiv, Ukraine, first interviewed in 1997, 11 years after the Chornobyl accident. The proposed follow-up field work will be conducted in 2004-05. Our 1997 study focused on children born between 2/1/85 -1/31/87 to families evacuated to Kyiv from the contaminated region around Chornobyl. The control group was composed of gender matched classmates and their mothers. The 1997 results showed that compared with controls, the evacuee mothers reported more health problems in their children, had more anxiety, depressive, somatic, and post-traumatic stress symptoms, and were more concerned about their health and their family's health because of the Chornobyl accident. At that time, there were few differences in the medical evaluations or self-reported well-being of the evacuee children, who were 10-12 years old, compared to classmate controls. We propose to extend our original study by reevaluating the cohort with the CIDI and other measures when the children are age approximately 18, i.e., when depressive, anxiety, and substance disorders emerge, and by including physical examinations and blood tests. This cohort is the highest risk group for thyroid cancer and thus the focus of increased societal concern. To redress the limitation of having only Kyiv controls, the study will be expanded to include population-based controls selected from participants in the national co-morbidity survey of Ukraine conducted in 2002 (MH61905) who are the same age as the evacuee children and live in areas uncontaminated by radiation. The response rate for the original study was close to 90%, and we anticipate a better than 90% follow-up rate because of the residential stability of the sample. The analysis will focus on a set of specific hypotheses, including the prediction that both groups of Kyiv children and mothers will be more symptomatic at follow-up, and that the evacuee teens will report significantly more somatic and psychological symptoms and Chornobyl-related anxiety and will have higher rates of affective, anxiety, and substance use disorders than classmate controls. We further predict that the Kyiv control mothers and children will be more symptomatic and fearful about Chornobyl than the population-based controls. In light of current events, the opportunity to further our understanding of responses to prolonged threat to health is a key strength.