Tissue Procurement Facility

组织采购机制的总体目标是采购和提供所需的组织 将标本提供给斯坦福大学癌症中心的研究人员，以支持他们与癌症相关的研究。 TPF的活动和服务包括收集和储存新鲜冷冻的肿瘤和正常组织 过量的手术材料和身体解剖，为活细胞研究提供新的肿瘤组织， 处理和储存癌症患者的血清样本，维护有链接的组织数据库 临床病理资料，提供组织学染色和病理复查，并协调 患者同意并确保法规遵从性。作为集中式共享资源，TPF添加了 通过体验、效率、标准化、责任感、患者保护实现价值 保密、及时地完成研究。一个咨询委员会就以下事项提供建议 设施政策和活动，并对服务请求进行科学和后勤审查。2005财年 TPF和卫星储存库已经向癌症中心成员提供了组织标本 代表了10个节目中的8个。该基金支持的研究重点包括 乳腺癌和前列腺癌临床相关基因表达亚型的发现。TPF还 提供一个连接专门“卫星”储存库库存的“虚拟银行”的门户，包括 血液学和神经外科标本的收集。未来的计划包括扩大 基于普遍同意的组织采购，加大对石蜡组织块和 活细胞，以及更详细的组织标本临床注释。

The overall objective of the Tissue Procurement Facility (TPF) is to procure and provide needed tissue specimens to Stanford University Cancer Center investigators to support their cancer-related research. TPF activities and services include collecting and banking freshly-frozen tumor and normal tissues from excess surgical material and from autopsy, providing fresh tumor tissue for viable cell studies, processing and banking serum specimens from cancer patients, maintaining a tissue database with links to clinicopathological data, providing histological staining and pathological review, and coordinating patient consent and assuring regulatory compliance. As a centralized Shared Resource, the TPF adds value through experience, efficiency, standardization, accountability, protection of patient confidentially, and timely completion of research. An advisory board provides recommendations on facility policies and activities, and performs scientific and logistical review of service requests. In FY2005 the TPF, and satellite repositories, have provided tissue specimens to Cancer Center members representing 8 out of 10 Programs. Highlights of the research supported by the Facility include the discovery of clinically-relevant gene-expression subtypes of breast and prostate cancers. The TPF also provides a portal to a "virtual bank" linking inventories of specialized "satellite" repositories, including collections of hematological and neurosurgical specimens. Future plans include an expansion of universal-consent based tissue procurement, increased efforts to bank both paraffin tissue blocks and viable cells, and more detailed clinical annotation of tissue specimens.