COMPREHENSIVE DIGITAL ATLAS OF MACAQUE BRAIN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目将使研究人员能够通过网络将猕猴和人类大脑研究的数据映射成高分辨率的三维大脑地图集。研究人员将能够自动观察和测量经典大脑结构、特定基因表达区域、大脑成像显示的激活区域以及其他实验数据之间的重叠。 现代基因组学和非侵入性成像技术使科学家能够扫描整个大脑，寻找基因表达或神经活动的焦点区域。这些技术在分析大脑的结构-功能关系方面有很大的希望，但它们不能很好地揭示大脑结构的解剖边界，使研究人员无法精确地识别基因参与或大脑激活相对于已知大脑结构的位置。该项目将允许研究人员从3D数字图谱中打印出任何角度和位置的大脑“切割”的横截面图，修改它们以匹配个体差异，并将其覆盖在实验组织学，MRI或PET切片上，以显示这些技术不可见的结构的近似边界。 猕猴脑图谱将通过合并由MRI、块面照片和组织学显微照片识别的脑结构的标志性边界来创建，以产生整个恒河猴（Macaca mulatta）脑的数字三维模板图谱。人脑图谱将由德国杜塞尔多夫海因里希海涅大学的于尔根·麦教授先前发表的部分创建。这些3D模型将存在于华盛顿大学国家灵长类动物研究中心的BrainInfo网站（http：braininfo.rprc.washington.edu）。其他机构的研究人员将能够通过网络将数据映射到地图集中，以便与其他机构映射的数据进行比较，或者将地图集转移到自己实验室的计算机上。 该项目将加速全世界神经科学家之间新研究成果的交流，并将提高我们对自闭症、痴呆症、抑郁症和精神分裂症等疾病所涉及的大脑区域的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will enable researchers to map data from studies of macaque and human brains over the Web into high-resolution 3-dimensional brain atlases. Investigators will be able to see and measure automatically the overlap between classical brain structures, areas in which specific genes are expressed, areas of activation revealed by brain imaging, and other experimental data. Modern genomics and noninvasive imaging technologies allow scientists to scan the whole brain for focal areas of gene expression or neural activity. These techniques hold great promise for analyzing structure-function relationships in the brain, but they do not reveal the anatomical boundaries of brain structures well enough for researchers to identify precisely the locations of genetic involvement or brain activation relative to known brain structures. This project will allow researchers to print-out cross-sectional maps of the brain 'cut' at any angle and position from 3D digital atlases, modify them to match individual variation, and overlay them on experimental histologic, MRI or PET sections to show the approximate boundaries of structures not visible by those techniques. The macaque brain atlas will be created by merging the landmark boundaries of brain structures identified by MRI, blockface photos and histological photomicrographs to produce a digital 3-dimensional template atlas of the entire rhesus (Macaca mulatta) brain. The human brain atlas will be created from sections previously published by Prof. Juergen Mai, of Heinrich Heine University, Duesseldorf Germany. The 3D models will reside in the BrainInfo website at the National Primate Research Center at the University of Washington (http://braininfo.rprc.washington.edu). Researchers at other institutions will be able to map data into the atlas over the Web for comparison with data mapped by others, or transfer the atlases to computers in their own laboratories. This project will accelerate the communication of new research findings among neuroscientists the world over and will improve our understanding of areas of the brain involved in such disorders as autism, dementia, depression and schizophrenia.