HBV AND 1018 ISS VACCINE FORMULATION IN NEWBORN BABOONS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一个两部分的研究。本实验的目的是首次在新生狒狒中测试由免疫刺激DNA序列（1018 ISS）与酵母重组乙型肝炎表面抗原（HBsAg）混合而成的乙型肝炎病毒（HBV）疫苗制剂的免疫原性。本实验将有助于确定该疫苗是否能在新生狒狒中引发抗体，并有助于确定1018 ISS的最佳剂量和最佳接种计划。这项研究将评估这种疫苗诱导狒狒对乙肝表面抗原产生抗体反应的能力，这种抗体反应相当于用于人类婴儿免疫的商业疫苗配方。从历史上看，成年狒狒已被证明是HBV疫苗的良好模型，例如那些含有HBsAg加1018 ISS的疫苗。这些研究将有助于确定HBV和ISS疫苗制剂是否可以在新生狒狒中引起与商业HBV疫苗相同的反应，这将有助于开发用于人类婴儿的新型HBV疫苗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a two-part study. The objective of this experiment is to test for the first time in newborn baboons the immunogenicity of a hepatitis B virus (HBV) vaccine formulation, consisting of immunostimulatory DNA sequences (1018 ISS) mixed with yeast-recombinant hepatitis B surface antigen (HBsAg). This experiment will help determine if this vaccine can elicit antibodies in newborn baboons, and help identify the optimal dose for 1018 ISS, and the optimal vaccination schedule. This study will evaluate the ability of this vaccine to induce an antibody response in baboons to HBsAg equivalent to a commercial vaccine formulation that is used to immunize human infants. Historically, adult baboons have shown to be a good model for HBV vaccines, such as those containing HBsAg plus 1018 ISS. These studies will help decide if the HBV and ISS vaccine formulation can elicit responses in newborn baboons equivalent to the commercial HBV vaccine, which will assist in the development of a new HBV vaccine for human infants.