HBSAG + HBSIC-1018 VACCINE INJECTION ROUTE COMPARISON

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。HBsIC配方由结合乙肝病毒表面抗原（HBsIC-1018）的免疫刺激DNA序列（ISS）组成。本实验的目的是评估注射途径-肌肉注射（IM）和皮下注射(SC) -对狒狒对HBsAg + HBsIC-1018制剂的免疫反应的影响。HBsAg-1018 ISS缀合物先前已在狒狒中进行了测试，当通过肌肉注射给药时，它显示出对HBsAg的强抗体反应。然而，HBsAg-1018 ISS配方从未通过皮下途径在狒狒中进行过测试。本实验将有助于确定免疫途径是否可以增强狒狒对HBsAg的体液和细胞介导的免疫反应。这项研究可能对社会有益，因为它将有助于开发新的/改进的HBV疫苗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HBsIC formulations consist of immunostimulatory DNA sequences (ISS) conjugated to hepatitis B virus surface antigen (HBsIC-1018). The objective of this experiment is to assess the effect of injection route ¿ intramuscular (IM) and subcutaneous administration (SC) - on the immune response of baboons to HBsAg + HBsIC-1018 formulation. An HBsAg-1018 ISS conjugate has been previously tested in baboons and it showed strong antibody responses to HBsAg when administered via intramuscular injection. However HBsAg-1018 ISS formulation has never been tested in baboons via the subcutaneous route. This experiment will help determine if immunization route can enhance the humoral and cell mediated immune responses of baboons to HBsAg. This study may be beneficial to society since it will help in the development of a new / improved HBV vaccine.