Susceptibility Weighted Imaging (SWI)

描述（由申请人提供）：磁敏感加权成像（SWI）已成为诊断脑部疾病的重要新工具。它用于研究大脑的血管系统，检测大脑中的铁，并使微血管可视化。该方法依赖于组织之间的磁化率的变化，其导致组织之间的相位差的引入和信号损失。它已被证明是一种强大的手段，可以更好地诊断创伤，中风和肿瘤，并检测大脑功能的变化。我们希望继续开发SWI：a）通过减少相位处理伪影使其在临床上更可行; B）通过创建人体组织的磁化率图来评估磁化率本身; c）通过同时收集MRA和SWI数据来研究其作为新的MR血管造影方法的作用;以及d）将其采集时间加速到对于全脑覆盖小于5分钟，而与任何并行成像增益因子无关。这些问题的解决方案不仅提供了一个先进的SWI目前的使用，但也引进了重要的新的研究方向的磁共振成像方法。为了实现这些目标，我们将进行模拟以模拟预期的人体条件，进行体模实验以建立技术的准确性，并进行人体实验以验证体内方法。拟议的研究将在四年内进行，早期部分用于技术开发，后期部分用于志愿者的潜在临床应用。这些研究将包括：对大脑中组织的敏感性进行成像，测量主要血管中的氧饱和度，并收集动脉和静脉的全脑血管信息。在测试提案的血管造影要素时，还将在使用和不使用造影剂的情况下对这些方法进行评价。这项研究计划的成功将为更好地检测神经和血管疾病提供一种手段。 公共卫生部门：磁敏感加权成像（SWI）是一种新的高分辨率磁共振成像方法，使其能够检测大脑中的微血管和铁含量。这种对血液制品（如含铁血黄素）和铁蛋白形式的铁的敏感性使SWI成为神经系统疾病（如创伤，中风，多发性硬化症和肿瘤）成像的首选方法。最近，SWI也可用于临床世界的日常使用，因此其持续的技术发展对于正确诊断患者的这些疾病至关重要。

DESCRIPTION (provided by applicant): Susceptibility weighted imaging (SWI) has become an important new tool for diagnosing disease in the brain. It is used to study the vasculature of the brain, to detect iron in the brain and to visualize micro-hemorrhages. The method relies on changes in susceptibility between tissues that lead to the introduction of phase differences between tissues and to signal loss. It has been shown to be a powerful means to better diagnose trauma, stroke and tumors and detect changes in brain function. We wish to continue the development of SWI to: a) make it more clinically viable by reducing phase processing artifacts; b) evaluate susceptibility itself by creating a susceptibility map of human tissue; c) study its role as a new MR angiographic method by simultaneously collecting MRA and SWI data; and d) speed up its acquisition time to less than 5 minutes for whole brain coverage, independent of any parallel imaging gain factor. The solution of these problems offers not only an advance over the current use of SWI but also the introduction of important new research directions in magnetic resonance imaging methods. To accomplish these goals, we will perform simulations to mimic expected human conditions, perform phantom experiments to establish the accuracy of the techniques, and perform human experiments to validate the methodology in vivo. The proposed research will take place over four years with the early parts devoted to technical development and the latter parts to potential clinical applications on volunteers. These studies will include: imaging the susceptibility of tissues in the brain, measuring oxygen saturation in major vessels and collecting whole brain vascular information for the arteries and veins. These methods will also be evaluated with and without contrast agents when it comes to testing the angiographic elements of the proposal. The success of this research program will offer a means to better detect neurological and vascular disease. PUBLIC HEALTH REVELANCE: Susceptibility Weighted Imaging (SWI) is a new high resolution magnetic resonance imaging method that makes it possible to detect microhemorrhages and iron content in the brain. This exquisite sensitivity to iron in the form of blood products (such as hemosiderin) and ferritin makes SWI the method of choice for imaging neurological diseases such as trauma, stroke, multiple sclerosis, and tumors. Recently, SWI has also become available to the clinical world for every day use and therefore its continued technical development is of paramount importance for the proper diagnosis of these diseases in patients.