课题基金 / 基金详情

STRUCTURAL STUDIES ON COMPLEX METAL-CONTAINING PROTEINS

STRUCTURAL STUDIES ON COMPLEX METAL-CONTAINING PROTEINS
复杂含金属蛋白质的结构研究
批准号：
7370332
负责人：
JOHN W PETERS
金额：
$0.77万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
项目状态：
已结题
起止时间：
2006-03-01 至 2007-02-28
来源：
https://reporter.nih.gov/project-details/7370332
关键词：
STRUCTURALSTUDIESCOMPLEXMETALCONTAINING

项目摘要

项目成果

JOHN W PETERS的其他基金

相似基金

相关文献

中文摘要
翻译
这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们正在使用X射线衍射法来解决有关几种含金属蛋白质的生化机制的问题。除了确定新型酶的结构外，我们的主要重点是各种酶的机械相关中间体的结构表征，目的是获得关于酶机制的信息。由于这些研究通常涉及结合底物和抑制剂的表征，它们与酶相互作用的细节只能用高分辨率的X射线衍射数据来揭示。目前，这种方法被应用于含金属的氢酶和固氮酶、各种磷酸酶以及与烯烃和酮的生物转化有关的酶。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are using x-ray diffraction methods to address issues concerning the biochemical mechanisms of several metal-containing proteins. In addition to determining the structures of novel enzymes, our main focus is the structural characterization of mechanistic relevant intermediates of various enzymes with the goal of obtaining information concerning enzyme mechanism. Since these studies are often concerned with the characteriztion of bound substrates and inhibitors, the details of their interaction with the enzymes can only be revealed with high resolution x-ray diffraction data. Currently, this approach is being applied to metal-containing hydrogenases and nitrogenases, various phosphatases, and enzymes involved in the bioconversion of alkenes and keto
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Defining the mechanistic determinants of catalytic bias in cofactor-based enzymatic oxidation-reduction reactions
  • 批准号：
    10874184
  • 项目类别：
  • 资助金额：
    $31.26万
  • 财政年份：
    2020
  • 负责人：
    JOHN W PETERS
  • 依托单位：
    UNIVERSITY OF OKLAHOMA
Defining the mechanistic determinants of catalytic bias in cofactor-based enzymatic oxidation-reduction reactions
  • 批准号：
    10034848
  • 项目类别：
  • 资助金额：
    $36.72万
  • 财政年份：
    2020
  • 负责人：
    JOHN W PETERS
  • 依托单位：
    WASHINGTON STATE UNIVERSITY
Defining the mechanistic determinants of catalytic bias in cofactor-based enzymatic oxidation-reduction reactions
  • 批准号：
    10437871
  • 项目类别：
  • 资助金额：
    $3.03万
  • 财政年份：
    2020
  • 负责人：
    JOHN W PETERS
  • 依托单位：
    WASHINGTON STATE UNIVERSITY
Defining the mechanistic determinants of catalytic bias in cofactor-based enzymatic oxidation-reduction reactions
  • 批准号：
    10259728
  • 项目类别：
  • 资助金额：
    $35.75万
  • 财政年份：
    2020
  • 负责人：
    JOHN W PETERS
  • 依托单位：
    WASHINGTON STATE UNIVERSITY
海外基金