PERMANENT SMALL ANGLE X-RAY SCATTERING STATION ON BEAM LINE 4-2

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。SSRL结构分子生物学小角X射线散射设施BL 4 -2是一个专门用于结构生物学研究的永久性实验站。它接收来自新的20极摇摆器光束的中央辐射风扇，该光束是去年SPEAR 3升级的一部分。摇摆器已经在一个减小的摇摆器磁场下运行，以管理光学部件上的热负荷，光学部件将在2006年夏季关闭期间升级。该设施自2004年成为专用车站以来一直全面运作，并一直超额认购。这是我们运行新仪器的第二年，它结合了传统的针孔几何小角散射相机和超小角散射设置。所有用户都大大受益于新的自动化样品到探测器距离变化能力，并能够覆盖所需的角度范围。USAXS装置今年被委托作为箱内系统的一个集成部分。我们的研究结果表明，在这一点上，集成仪器已达到的基本规格相媲美的旧的独立USAXS仪器。在具体的分项目中说明了显著的硬件和软件改进。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The SSRL Structural Molecular Biology small-angle x-ray scattering facility BL4-2 is a permanent experimental station dedicated for structural biology studies. It receives the central fan of radiation from the new 20-pole wiggler beam, which was installed as a part of the SPEAR3 upgrade last year. The wiggler has been operated at a reduced wiggler field to manage thermal load on the optic components, which will be upgraded during the summer shutdown in 2006. This facility has operated fully since becoming a dedicated station in 2004 and has been oversubscribed at all times. This has been our second year of running the new instrument, which combines the conventional pin-hole geometry small angle scattering camera and the ultra small angle scattering setup. All users benefited significantly from the new automated sample-to-detector distance change capability and were able to cover desired angular ranges. The USAXS setup was commissioned as an integrated part of the in-hutch system this year. Our results show that the integrated instrument has at this point achieved the basic specifications comparable to those of the older stand-alone USAXS instrument. Notable hardware and software improvements are described within the specific subprojects.