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HCV founder viruses as vaccine targets

HCV founder viruses as vaccine targets
HCV 创始人病毒作为疫苗目标
批准号:
nhmrc : 1042090
负责人:
A/Pr Fabio Luciani
金额:
$34.73万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31

项目摘要

项目成果

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中文摘要
翻译
大多数感染丙型肝炎病毒(HCV)的个体发展为进行性肝病。目前迫切需要一种疫苗,这种疫苗需要模仿在少数清除感染的个体中看到的免疫反应。然而,我们对这些反应的理解存在很大差距,因为大多数急性感染不会引起疾病,而且不会引起注意。该项目将通过对大量早期感染的受试者进行详细的免疫学和病毒学分析来填补这些空白。
英文摘要
Most individuals infected with hepatitis C virus (HCV) develop progressive liver disease. A vaccine is urgently needed, and needs to mimic the immune responses seen in the minority of individuals who clear infection. However, there are large gaps in our understanding of these responses as most acute infections cause no illness and pass unnoticed. This project will fill these gaps by detailed immunological and virological analysis of a large group of subjects with early infection.
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