NUTRITION SUPPORT IN PEDIATRIC STEM CELL TRANSPLANTATION - A RCT

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。具体目的/目的：由于严重的粘膜炎和准备方案的其他胃肠道并发症，接受干细胞移植的儿童通常需要肠外营养来提供足够的热量和蛋白质。准确的能量供应可能会减少与喂食过多(2)或喂食不足(3)相关的并发症。我们假设SCT期间身体成分的变化会影响REE，这些患者的标准营养管理方法可能会导致过度喂养。我们提出了一项前瞻性随机对照试验，比较标准营养支持方法和提供能量摄入以准确满足间接量热法测量的静息能量消耗的方法的营养效果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aims/Objectives: Children undergoing stem cell transplantation often require parenteral nutrition to provide adequate calories and protein due to severe mucositis and other gastrointestinal complication of the preparative regimen (1). Accurate provision of energy may reduce complications related to overfeeding (2) or underfeeding (3). we hypothesize that changes in body composition during SCT affect REE, and that the standard approach to nutritional management of these patients may lead to overfeeding. We propose a prospective, randomized controlled trial to compare the nutrional effects of the standard method of nutritional support with an approach in which energy intake is provided to exactly meet resting energy expenditure as measured by indirect calorimetry.