INFLAMMATORY GENE POLYMORPHISMS IN CARDIAC SURGERY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。体外循环(CPB)是全身炎症反应的有效触发因素，包括激活白细胞和产生多种促炎介质。其后果包括多器官系统功能障碍、毛细血管渗漏、凝血改变，并增加发病率和死亡率。[1]在脓毒症中，炎症反应在机制和临床上与体外循环相似，特定炎症基因的多态性与炎症细胞因子产生的改变和死亡率的增加有关。基于这一信息，我们提出了一项前瞻性观察研究，以探讨炎症基因多态、循环炎症介质的产生与婴儿体外循环心脏手术的临床结局之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiopulmonary bypass (CPB) is a potent trigger of the systemic inflammatory response, which includes activation of leukocytes and producation of multiple pro-inflammatory mediators. Its consequences includes multi-organ system dysfunction, capillary leak, altered coagulation, and increased ,orbidity and mortality. [1] In sepsis, a condition in which the inflammatory response shares mechanistic and clinical simularities to that seen with CPB, polymorphisisms of specific inflammatory genes have been associated with alterations in inflammatory cytokine production and increased mortality. Based upon this information, we propose a prospective observational study to investigate the realationship between inflammatory gene polymorphisms, produaction of circulating inflammatory mediators, and clinical outcome for infants undergoing cardiac surgerywith CPB.