GENETICS OF AUTISTIC DISORDER

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目名为《自闭症的神经生物学和遗传学》，旨在更多地了解自闭症(AD)的病因(S)。评估核心是该项目的数据收集中心。作为这项研究的一部分，研究参与者将接受初步评估，其中包括自闭症诊断观察表(ADOS)和自闭症诊断面谈(ADI)，以确定研究资格。随后，他们将接受智力、学业成就、执行功能以及语言和交流功能的测试。将完成全面的遗传学评估，其中将包括临床检查、广泛的家族史(家谱)和血液样本，以供未来尝试识别可能在自闭症中发挥作用的基因(S)。除上述外，《自闭症的神经生物学和遗传学》由另外两个项目组成。项目2，核磁共振，旨在通过对诊断为阿尔茨海默病的儿童进行核磁共振扫描来确定大脑结构的变化。项目3，回归，通过观看儿童在生命的头两年的发展的录像带记录，研究自闭症儿童的发育里程碑丢失的现象。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the project, "The Neurobiology and Genetics of Autism", is to learn more about the cause(s) of Autistic Disorder (AD). The Assessment Core serves as the data collection hub for the project. As part of this, study participants undergo an initial assessment that includes the Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview (ADI) to determine study eligibility. Following, they will undergo tests of intelligence, academic achievement, executive function, and language and communication function. A full genetics evaluation will be completed, which will include a clinical examination, an extensive family history (pedigree), and a blood sample for future attempts to identify the gene(s) that may play a role in autism. In addition to the above, "The Neurobiology and Genetics of Autism" is composed of two other projects. Project 2, MRI, is designed to determine the changes in brain structure using MRI scans for children diagnosed with AD. Project 3, Regression, studies the phenomenon of lost developmental milestones in children with autism by viewing videotape records of the children's development during the first two years of life.