GENETICS OF BONE STRENGTH IN MEN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。髋关节相关的骨质疏松性骨折，特别是髋部骨折，是美国和世界范围内的主要健康问题。骨质疏松相关的骨强度下降是骨质疏松性骨折的主要危险因素。骨强度的组成部分是高度遗传的，在我们使用绝经前姐妹对的研究中，我们发现了与骨量和骨结构的几种测量方法的联系。关于男性骨强度的遗传度研究非常有限。此外，对小鼠的研究表明，性别特异性基因可能是男性和女性之间骨骼强度差异的基础。本研究将检验的假设是，男性骨量、骨结构、骨质量和骨转换具有遗传决定的成分，并且在数量上与我们在女性中建立的相似。然而，虽然许多基因座在两性中是相同的，但某些基因座是性别特异性的。通过双能X线吸收测定法测量的骨骼部位为右股骨颈、转子和Wards、腰椎L2至L4和全身。在标准X线设备上拍摄骨盆下部和股骨上部内旋15度的X线片。使用数字卡尺在右髋上进行所有结构测量（与DXA测量的相同）。将采集空腹血液和尿液，用于测量钙调节激素和骨转换的生化标志物。人体测量是在专用仪器上测量的;全身瘦和脂肪是通过DXA测量的。问卷包括个人、家庭和病史、用药史、吸烟、体力活动和饮食问卷。所有调查问卷均经过验证，并在GCRC第578号方案中使用了五年。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Age-related osteoporotic fracture, particularly hip fracture, is a major health problem in the United States and worldwide. Age-related decrease in bone strength is a major risk factor for osteoporotic fracture. Components of bone strength are highly heritable, and in our studies using premenopausal sister pairs, we have detected linkage to several measures of both bone mass and bone structure. Heritability studies on measure of bone strength in men are very limited. Futhermore, studies in mice suggest that sex specific genes may underlie differences in bone strength between men and women. The hypothesis that will be tested in this study is that in men bone mass, bone structure , bone quality and bone turnover have components that are genetically determined and are similar in magnitude to those we have established in women. However, while many loci will be the same in both sexes, certain loci will be sex specific. The skeletal sites that are being measured by dual X-ray absorptiometry are right femoral neck, trochanter and wards, lumbar vertebrae L2 to L4 and total body. Radiographs of the lower pelvis with upper femura in 15 degrees internal rotation are taken on standard X-ray equipment. All structural measurements are made on the right hip (the same measured by DXA) using a digital caliper. Fasting blood and urine will be collected for measurement of calcium regulating hormones and biochemical markers of bone turnover. Anthropometrics are measured on dedicated instruments; total body lean and fat are measured by DXA. The questionnaires include personal, family and medical history, medication history, smoking, physical activity and dietary questionnaires. All questionnaires have been verified and have been use over the last five years in GCRC Protocol 578.