TESTOSTERONE EFFECTS ON BONE AND FRAILTY IN MEN WITH OSTEOPOROSIS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。对骨质疏松症的关注在很大程度上强调了妇女的健康，而很少关注男性骨质疏松性骨折的诊断和预防。然而，这种疾病对男性来说也是一个重要的问题。睾酮水平随着年龄的增长而下降，严重的睾酮缺乏与骨量减少和骨折有关。一些流行病学研究表明，在老年男性中，低睾酮与低骨量有关，但这一发现并不一致。髋部骨折的男性被发现比对照组更容易出现睾丸素缺乏。在70岁以上睾酮水平低于年轻正常范围的男性中，我们发现生物可利用睾酮的差异可以解释股骨颈骨密度(FN BMD)值差异的20%。在这个人群中，FN骨密度的其他预测因素包括体重指数和体力活动，这两个参数被描述为脆弱。根据这些数据，补充睾丸素可能对老年男性的骨骼健康和脆弱很重要。我们将验证补充睾丸素可以增加髋部骨折老年男性骨密度的假设。我们还将评估睾丸激素对身体健康和虚弱的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Attention to osteoporosis has largely emphasized women's health, and little attention has focused on the diagnosis and prevention of osteoporotic fractures in men. And yet the disease is also an important problem in men. Testosterone levels decline with advancing age, and severe testosterone deficiency is associated with low bone mass and fracture. Several epidemiologic studies suggest that low testosterone is associated with low bone mass in older men, but this finding is not consistent. Men with hip fracture are found to be testosterone deficient more often than control subjects. Among men over age 70 with testosterone levels below the young normal range, we found differences in bioavailable testosterone accounted for 20% of the variance in femoral neck bone mineral density (FN BMD) values. Additional predictors of FN BMD in this population incuded body mass index and physical activity, two described parameters of frailty. Based on these data, testosterone supplementation may be important for bone health and frailty in older men. We will test the hypothesis that testosterone supplementation can increase bone mineral density in older men with hip fracture. We will also evaluate the effects of testosterone on physical health and frailty.