PACTG 1026S

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这是一项前瞻性的PK研究，旨在评估目前处方的抗逆转录病毒药物以及这些药物在感染艾滋病毒的怀孕妇女中的相互作用组合的药代动力学。主要目的是描述选定的抗逆转录病毒妇女在怀孕期间的药代动力学(PK)参数，并确定与a)未怀孕成人的历史数据和b)研究队列中的相同妇女在产后期间的历史数据相比，这些抗逆转录病毒药物的治疗剂量方案在怀孕期间是否产生足够的药物暴露。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prospective PK study to evaluate the pharmacokinetics of currently prescribed antiretroviral drugs and interacting combinations of these drugs in pregnant HIV-infected women. The primary objective is to describe the pharmacokinetic (PK) parameters during pregnancy of selected antiretroviral women, and to determine if therapeutic dosing regimens of these antiretroviral drugs produce adequate drug exposure during pregnancy compared to a) historial data from non-pregnant adults and b) the same women in the study cohorts during the post partum period.