ROLE OF INFANT FEEDING IN CHILDHOOD ALLERGY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。婴儿喂养在儿童过敏中的作用是一项前瞻性观察研究，对哮喘和非哮喘母亲及其婴儿在出生2周内进行登记，并随访至产后9-12个月。本研究的目的是1)比较9-12月龄母乳喂养和非母乳喂养婴儿的外周细胞因子表型，考虑母亲哮喘史；2)比较哮喘母亲和非哮喘母亲的乳汁细胞因子表型；3)考虑母亲哮喘史和母婴细胞因子基因型，研究母乳中细胞因子浓度与婴儿外周细胞因子表型的关系。同意参与的合格母亲在产后2-3周完成一份基线问卷。收集与产妇健康史、出生史、婴儿喂养、产妇饮食和人口特征有关的数据。大约产后4周，在家中从所有母乳喂养的母亲那里采集母乳样本。然后对所有受试者每月完成问卷调查，收集有关婴儿和母亲疾病、哮喘严重症状和婴儿喂养的数据。所有问卷均以电话访谈方式完成。在产后9-12个月，在一次门诊研究访问期间收集所有母亲和婴儿的血液样本。母亲和婴儿的过敏皮肤测试也在这次访问中完成。受试者被转介到他们的医生或过敏专科医生随访任何阳性的皮肤测试结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Role of Infant Feeding in Childhood Allergy is a prospective observational study of asthmatic and non-asthmatic mothers and their infants enrolled within 2 weeks of birth and followed through 9-12 months postpartum. The aims of the study are to 1) compare the peripheral cytokine phenotypes of breastfed and non-breastfed infants between 9-12 months of age, accounting for maternal history of asthma, 2) compare the cytokine phenotypes of the milk of asthmatic and non-asthmatic mothers, and 3) examine the relationship between cytokine concentrations in maternal milk and the infants' peripheral cytokine phenotypes, accounting for maternal history of asthma and maternal and infant cytokine genotypes. Eligible mothers who consent to participate complete a baseline questionnaire at 2-3 weeks postpartum. Data related to maternal health history, birth history, infant feeding, maternal diet, and demographic characteristics is collected. A sample of human milk is collected at home from all breastfeeding mothers approximately 4-weeks postpartum. Monthly questionnaires are then completed for all subjects to collect data on infant and maternal illness, asthma severity symptoms, and infant feeding. All questionnaires are completed by telephone interview. At 9-12 months postpartum, a blood sample is collected for all mothers and infants during the one outpatient study visit. Allergy skin testing for the mother and her infant is also completed at this visit. Subjects are referred for follow-up with their physician or an allergist for any positive skin test results.