MECHANISMS OF CHROMIUM'S EFFECT ON INSULIN SENSITIVITY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。虽然有几种药物可以有效地治疗与2型糖尿病相关的胰岛素抵抗，但饮食补充剂吡喃甲酸铬对艾滋病毒患者有特殊的优势。这种膳食补充剂已被证明可以改善2型糖尿病患者的胰岛素敏感性。这个试点项目将研究1000微克铬作为吡啶甲酸铬对HIV疾病胰岛素抵抗的影响。铬补充剂将在4个月的疗程中每天服用，胰岛素敏感性将在基线以及治疗2个月和4个月后进行测定。可能的毒性将每两周监测一次。这一初步数据将被用作一项更大规模的铬改善胰岛素敏感性机制研究的初步数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although several drugs are effective in treating the insulin resistance associated with Type 2 diabetes mellitus, the dietary supplement chromium picolinate has particular advantages for patients with HIV-disease. This dietary supplement has been shown to improve insulin sensitivity in patients with Type 2 diabetes mellitus. This pilot project will investigate the effect of 1000 ug of chromium as chromium picolinate on the insulin resistance of HIV disease. Chromium supplements will be given daily over a 4 month course of treatment and the insulin sensitivity will be determined at baseline and after 2 and 4 months of therapy. Possible toxicity will be monitored every 2 weeks. This pilot data will be used as preliminary data for a larger study on the mechanism by which chromium improves insulin sensitivity.