NATURAL HISTORY STUDY OF THE DEVELOPMENT OF TYPE 1 DIABETES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。1型糖尿病（T1D）是一种由胰腺β细胞破坏引起的疾病。它可以发生在任何年龄，但发病率最高的是儿童和青少年。虽然所有人都易患此病，但患有T1D的人的亲属患此病的风险要大得多。T1D发展的TrialNet自然历史研究的目标是获得有关T1D发病机制和自然历史的信息，并促进招募和评估可能符合T1D预防试验资格的个体。重要的是，从这项研究中获得的信息将有助于开展和实施预防试验。本协议中描述的T1D发展的TrialNet自然历史研究的设计旨在实现这些目标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 1 diabetes (T1D) is a disease that results from the destruction of pancreatic beta-cells. It can occur at any age, but its incidence is highest in children and adolescents. Although all people are susceptible, relatives of individuals with T1D are at much greater risk for development of the disease. The goals of the TrialNet Natural History Study of the Development of T1D are to both gain information about the pathogenesis and natural history of T1D and to facilitate the recruitment and assessment of individuals who might qualify for T1D prevention trials. Importantly, the information obtained from this study will serve to enable the development and implementation of prevention trials. The design of the TrialNet Natural History Study of the Development of T1D as described in this protocol is intended to achieve these goals.