GNRH AGONIST TEST

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一个新协议，它是两个前协议#6585和#9214的简化合并。它提出了测试的总体假设，激素反应注射的挑战剂量的GnRH激动剂（GnRHag）将区分青春期障碍以及睡眠测试。具体来说，我们将测试对注射GnRH激动剂醋酸leuprolide的反应将区分性早熟和性早熟延迟的原因的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a new protocol that is a simplified merger of two former protocols, #6585 and #9214. It proposes to test the overall hypothesis that the hormonal responses to injection of a challenge dose of GnRH agonist (GnRHag) will distinguish among disorders of puberty as well as a sleep test. Specifically, we will test the hypotheses that the response to injection of the GnRH agonist leuprolide acetate will distinguish among the causes of precocious puberty and among the causes of delayed puberty.