EFFECT OF EDUCATION AND DRUG PRESENTATION ON EFFICACY OF MONTELUKAST IN ASTHMA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这是一项由研究人员发起的多中心方案，旨在研究全国600名患者的安慰剂效应。轻度哮喘患者随机接受Singulair或安慰剂治疗，并进一步随机接受2x2格式的强化“非药物”干预或不干预。第五组接受通常的护理。非药物干预措施包括使用大的蓝色胶囊(与小的白色胶囊相比)、多媒体教育计划，以及为护士协调员开护理员处方。对患者进行为期6周的随访。主要终点是肺活量测定法测得的峰值流量。这项研究并不要求安慰剂组因为登记而在基线治疗中有任何减少。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is an investigator-initiated multicenter protocol to study the placebo effect in 600 patients nationwide. Patients with mild asthma are randomized to Singulair or placebo and further randomized to enhanced "non-drug" interventions or no intervention in a 2 x 2 format. A fifth group receives usual care. Non-drug interventions include the use of big blue capsules (versus small white ones), multimedia educational programs, and caregiver prescriptions for nurse coordinators. Patients are followed for 6 weeks. The primary endpoint is peak flow as measured by spirometry. The study does not require the placebo group to have any reduction in their baseline treatment because of enrollment.