PACTG P1045: PREVALENCE OF ABNORMALITIES IN VERTICALLY HIV-INFECTED CHILDREN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这是一项儿科ACTG的多中心试验，旨在检查垂直获得HIV感染的儿童和青少年与未感染HIV的儿童的形态学和代谢异常的患病率。这是一项横断面研究，旨在检查葡萄糖代谢、脂质水平、身体成分、脂肪沉积和骨密度。一个重要的变量将是抗逆转录病毒（ARV）方案的性质（是否包括蛋白酶抑制剂）。受试者将按坦纳分期分层。纽约大学的预期参与人数为40例受试者x 3次门诊访视。这是一项非常重要的研究，因为越来越多的异常证据以及诊断和干预的必要性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a multicenter trial of the Pediatric ACTG to examine the prevalence of morphologic and metabolic abnormalities in children and adolescents who acquired HIV infection vertically, in relation to HIV-uninfected children. It is a cross-sectional study to examine glucose metabolism, lipid levels, body composition, fat deposition and bone density. An important variable will be the nature of the antiretroviral (ARV) regimen (whether including protease inhibitor or not). Subjects will be stratified by Tanner stage. Anticipated involvement at NYU is 40 subjects x 3 outpatient visits. This is a very important study due to the increasing evidence of abnormalities and the need to diagnose and intervene.