TREATMENT OPTIONS FOR TYPE 2 DIABETES IN ADOLESCENTS AND YOUTH (TODAY)

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。在美国，儿童2型糖尿病的发病率正在以惊人的速度增长，特别是在少数民族人群中。这表明，这种增加反映了当今美国儿童肥胖症的患病率增加。青少年和青年2型糖尿病的治疗选择（今日）是一项为期5年的多中心临床试验。俄克拉荷马州大学健康科学中心是全国12个治疗中心之一，为这个NIDDK/NIH资助的项目。该试验将比较药物和强化生活方式干预对750名2型糖尿病儿童和青少年的影响。今天将确定国家和国际上对患有这种慢性疾病的儿童的护理标准。从2003年开始，大约120名俄克拉荷马州10岁至17岁的儿童将有机会参加。美洲原住民、非洲裔美国人和西班牙裔人口患这种疾病的风险更大，将特别强调招收这些族裔群体的儿童。参与者必须有2型糖尿病的诊断少于2年的持续时间。试验期间将提供研究药物、供应品、费用报销和奖励。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The incidence of type 2 diabetes in children is increasing at an alarming rate in the US, especially among minority populations. It is suggested that this increase reflects the increased prevalence of childhood obesity in the US today. Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) is a 5-year, multi-center clinical trial. The University of Oklahoma Health Sciences Center is one of the twelve treatment centers across the county for this NIDDK/NIH funded project. The trial will compare the effects of medications and intensive lifestyle interventions in 750 children and adolescents with type 2 diabetes. TODAY will define the standard of care for children with this chronic disease, nationally and internationally. Beginning in 2003, approximately 120 Oklahoma children ages 10 years to 17 years will have an opportunity to participate. Native American, African Americans and Hispanic populations are at greater risk of developing this disease, and special emphasis will be given to enrolling children in these ethnic groups. Participants must have a diagnosis of type 2 diabetes of less than 2 years of duration. Study medications, supplies, reimbursement of costs, and incentives will be provided during the course of the trial.