GENERAL CLINICAL RESEARCH CENTER

描述(由申请人提供)：马里兰大学医学院近年来在研究经费方面有了显著的增长，本年度的研究经费总额为3.41亿美元。作为该机构维护和扩展基础设施以促进高质量临床和转化研究的承诺的一部分，我们于2002年在马里兰大学医学中心建立了一个综合临床研究中心。GCRC的目标是为医学科学家提供临床研究的环境和资源，确保研究和培训将是最高质量的。这个中心一直是密歇根大学的一项非凡资产。GCRC整合了一个以前支离破碎的临床研究企业，并在整个机构范围内产生了朝着共享资源和更高研究标准的文化变革。 在最初的四年里，GCRC支持了代表医学院、牙科和药学学院内广泛学科的议定书。GCRC的设施对许多项目的实施至关重要，包括需要隔离病房测试传染病病原体和活疫苗候选的项目。利用GCRC的临床资源，五年前无法完成的项目现在是可能的。生物统计和生物信息学核心的可用性被GCRC调查人员广泛利用，并为无数研究的质量和管理做出了贡献。GCRC支持的基因组学核心设施已经成为希望探索疾病的遗传基础或致病细菌的遗传学的多名研究人员的大量订阅的核心资源。GCRC研究主题倡导者被高度视为关于研究行为的伦理和后勤咨询的资源。GCRC已成为校园临床研究培训的重点。马里兰大学临床研究课程发展K30奖和多学科临床研究职业发展路线图K12奖与GCRC密不可分。 在这次延期中，我们利用节约成本的措施和机构支持，要求在三年期间，由于通货膨胀的影响，预算的总体增幅不超过3%。在即将到来的赠款期间，我们期待着密歇根大学临床和转化科学中心的规划和资金。

DESCRIPTION (Provided by Applicant): The University of Maryland (UM) School of Medicine has experienced remarkable growth in research funding in recent years, totaling $341 million in the current year. As part of the institution's commitment to maintaining and expanding infrastructure to facilitate high-quality clinical and translational research, we established a General Clinical Research Center in the University of Maryland Medical Center in 2002. The goal of the GCRC is to provide medical scientists with a setting and resources for clinical research that will ensure that research and training will be of the highest quality. This Center has been a remarkable asset to UM. The GCRC has consolidated a previously fragmented clinical research enterprise and produced an institution-wide cultural change toward shared resources and higher standards of research. In its first four years, the GCRC has supported protocols representing a wide range of disciplines within the School of Medicine and the Schools of Dentistry and Pharmacy. The GCRC facilities are essential to the conduct of numerous projects, including projects requiring an isolation ward for testing infectious agents and live vaccine candidates. Projects that could not have been done five years ago are now possible with the clinical resources of the GCRC. The availability of Biostatistical and Biolnformatics Cores is widely exploited by GCRC investigators and has contributed to the quality and management of innumerable studies. The GCRC-supported Genomics Core Facility has become a heavily subscribed core resource for multiple investigators who wish to explore the genetic basis of disease or the genetics of pathogenic bacteria. The GCRC Research Subject Advocate is highly regarded as a resource for consultation about the ethics and logistics of study conduct. The GCRC has become a focus for training in the clinical research on campus. The University of Maryland's K30 award for Clinical Research Curriculum Development and its Roadmap K12 award for Multidisciplinary Clinical Research Career Development are inextricably integrated with the GCRC. In this renewal, using cost-saving measures and institutional support, we have requested no overall increase in budget beyond a 3% increase for inflation for a 3-year period. During the upcoming grant period, we anticipate the planning and funding of the UM Clinical and Translational Science Center.