TRIAL OF ANTENATAL CORTICOSTEROID REGIMENS IN PTS AT RISK FOR PRETERM DELIVERY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这是一项随机、双盲、安慰剂对照的前瞻性多中心临床试验，旨在探讨重复给予皮质类固醇对胎儿成熟的疗效和风险。将在孕龄小于32周、有早产风险且在类固醇初始疗程后妊娠超过7天的患者中比较两种皮质类固醇治疗方案。患者将随机接受皮质类固醇每周疗程，持续4周，直至妊娠34周或分娩，或接受安慰剂每周疗程。将在MHMC招募约150-200名妊娠23-32周的早产高风险妇女。婴儿将接受为期三年的长期随访。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a randomized, double-blind placebo controlled prospective multi-center clinical trial designed to address the efficacy and risk associated with repetitive dosing of corticosteroids on fetal maturation. Two corticosteroid treatment regimens will be compared in patients less than 32 weeks gestation at risk for preterm delivery who remain pregnant more than 7 days after an initial course of steroids. Patients will be randomized to receive weekly courses of corticosteroids for either 4 weeks, until 34 weeks gestation or delivery, or to receive weekly courses of placebo. Approximately 150-200 women at MHMC between 23-32 weeks gestation at high risk for preterm delivery will be recruited. Infants will have long term follow-up for three years.