LOW DOSE INHALED NITRIC OXIDE TO PREVENT CHRONIC LUNG DISEASE IN PRETERM INFANTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这是一项多中心、随机、盲目的临床试验，目的是调查低剂量吸入一氧化氮是否会增加月经后36周无慢性肺部疾病的早产儿的存活率，这些早产儿出生时体重为500-1250克，在出生后7天仍需要机械通气或持续体位气道压力。这项研究还将通过评估毒性和评估两岁儿童的神经发育结果来评估这种疗法的安全性。招生目标是4年内585名婴儿。受试者在9-12个月的校正年龄和22-26个月的校正年龄进行两次门诊检查，以持续评估婴儿的生长和发育。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a multi-center, randomized, blinded clinical trial to investigate whether low-dose inhaled nitric oxide administered to preterm infants of 500-1250 g birth weight who continue to require mechanical ventilation or continuous position airway pressure at 7 days of age will increase survival without chronic lung disease at 36 weeks postmenstrual age. The study will also evaluate the safety of this therapy by assessing toxicity and assessing neurodevelopmental outcome through two years of age. The enrollment goal is 585 infants over 4 years. Subjects have two outpatient visits at 9-12 months corrected age and 22-26 months corrected age for ongoing evaluation of the baby's growth and development.