SC COBRE IN LIPIDOMICS AND PATHOBIOLOGY: ADMIN CORE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。描述（由申请人提供）：MUSC是一个新兴的卓越中心，在生物医学研究与几个关键领域的特殊优势，它可以建立未来的增长和发展。这些领域之一是基于对生物活性脂质及其结构、代谢和功能的研究。该研究领域的范围及其在MUSC的发展允许过渡到对生物活性脂质（本文称为脂质组学）及其对哺乳动物病理生理学的贡献的全球研究。因此，这个COBRE的组织假设指出，生物活性脂质的多样性提供了丰富的调节细胞功能的途径网络。这些途径的扰动有助于重要的病理生物学过程，如癌症进展、转移、衰老和真菌发病机制。该提案的具体目标是建立一个互动的脂质组学和病理学中心，以促进MUSC研究的发展和卓越。这将通过追求以下具体目标来实现：（1）指导最初的五名有针对性的初级研究者，以开发独立的NIH资助的研究;（2）开发新颖和关键的科学核心;（3）招募更多具有关键专业知识的独立研究者;（4）通过开发特定的项目项目来维持COBRE的增长。这些活动应该导致一个高度发达的中心，在一个不断发展的研究领域具有重要的生物医学卓越的临界质量，对癌症生物学，衰老，炎症和传染病具有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The MUSC is an emerging center of excellence in biomedical research with a few key areas of exceptional strength upon which it can build future growth and development. One of these areas is based on the study of bioactive lipids, their structure, metabolism, and function. The scope of this field of research and its development at MUSC allow a transition to global studies on bioactive lipids (designated herein as Lipidomics) and their contribution to mammalian pathophysiology. Thus, the organizing hypothesis of this COBRE states that the diversity of bioactive lipids provides a rich network of pathways that regulate cell function. Perturbations of these pathways contribute to important pathobiologic processes such as cancer progression, metastasis, aging, and fungal pathogenesis. The specific goal of this proposal is to develop an interactive Center of Lipidomics and Pathobiology that will promote the growth and excellence of research at MUSC. This will be achieved by pursuing the following specific aims (1) Mentor an initial group of five targeted junior investigators to develop independent NIH-funded research; (2) Develop novel and critical scientific cores; (3) Recruit additional independent investigators with key expertise; (4) Sustain the growth of the COBRE through the development of specific program projects. These activities should result in a highly developed Center with a critical mass of biomedical excellence in an evolving area of research highly significant to cancer biology, aging, inflammation, and infectious diseases.