BIOINFORMATICS CORE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该核心的主要职责是管理和分析微阵列数据，与位于俄勒冈大学诺曼分校、俄勒冈州立大学和德克萨斯大学校区的INBRE微阵列核心(OMRF)和卫星生物信息学核心进行协调。我们的努力旨在将这些团体的活动整合为一个连贯的整体。这些努力的一个基本工具将是每个校区的生物信息学人员定期开会，这是一项最初始于俄克拉何马州的成功战略。我们推广使用迈阿密和MAGE标准的常用工具，并充当提交给NCBI GEO的中央数据存储库；MAGE对这项工作至关重要。俄克拉荷马州重新注解(OKRA)项目。秋葵项目的重点将是让本科生参与微生物基因组序列数据库的重新注释。目前，微生物基因组学中最令人头疼的问题之一是缺乏对现有微生物基因组序列数据库的持续管理。供资机构通常不愿将资源用于管理或重新注释，而且更新这些数据库通常是随意和不统一的。此外，重新注释通常需要付出相当大的努力，但几乎没有学术回报(这是一种抑制因素)。我们正在使用微生物基因组序列重新注释来向俄克拉荷马州的本科生介绍基因组序列数据的生物信息学分析，并更新和增强现有微生物基因组序列数据库的注释。沟通。生物信息学核心所满足的一个明显需求是更好的校际交流。我们广泛传播有关核心设施活动的信息。我们每季度出版一份时事通讯，并主持一个网站(http://microgen.ouhsc.edu).我们已经实施了俄克拉荷马州生物信息学用户S小组(OBUG)，并建立了一个网站(http://obug.ouhsc.edu/))，我们打算成为俄克拉荷马州生物信息学交流的信息交换所。关于微阵列数据库的通信、共性和互操作性等问题是一个令人关切的问题。因此，我们希望这个用户群成为专家和新手都能来讨论生物信息学问题、想法和解决方案的地方，发布教程和书评等内容，并普遍分享信息。最后，生物信息学核心发起了基因组学/蛋白质组学/生物信息学讨论小组，该小组是在俄克拉荷马州布林的赞助下开始的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A major responsibility of this core is database management and analysis of microarray data, coordinated with the INBRE Microarray Core (at OMRF) and the satellite bioinformatics cores located on the OU Norman, OSU and UT campuses. Our efforts are directed towards integrating the activities of these groups into a coherent whole. A fundamental tool for these efforts will be the periodic meeting of the bioinformatics personnel from each of the campuses, a successful strategy originally begun in the Oklahoma BRIN. We promote the use of common tools using the MIAMI and MAGE standards, and act as a central data repository for submission to the NCBI GEO; MAGE is essential for this effort. The Oklahoma Re-Annotation (OKRA) Project. The focus of the OKRA project will be to engage undergraduate students in re-annotation of microbial genome sequence databases. Currently, one of the most vexing problems in microbial genomics is the paucity of ongoing curation of the existing microbial genome sequence databases. Funding agencies have typically been reluctant to devote resources to curation or re-annotation, and updating these databases has generally been haphazard and non-uniform. Further, re-annotation typically involves considerable effort but little academic reward (a disincentive). We are using microbial genome sequence re-annotation to introduce Oklahoma undergraduate students to bioinformatic analyses of genome sequence data, and update and enhance the annotation of existing microbial genome sequence databases. Communication. An obvious need fulfilled by the Bioinformatics Core is better intercampus communication. We disseminate information widely concerning core facility activities. We publish a quarterly newsletter and host a website (http://microgen.ouhsc.edu). We have implemented the Oklahoma Bioinformatics User?s Group (OBUG), with a website (http://obug.ouhsc.edu/) that we intend to be a clearinghouse for bioinformatics exchanges in Oklahoma. Communication on microarray database commonality and interoperability and other issues are a concern. Therefore, we want this users group to be a place where experts and novices alike will come to discuss bioinformatics problems, ideas, and solutions, post things like tutorials and book reviews, and generally share information. Lastly, the Bioinformatics Core sponsors the Genomics/Proteomics/Bioinformatics Discussion Group that began under the auspices of the Oklahoma BRIN.