South Carolina Center for Clinical /Translational Resear

描述(申请人提供)：南卡罗来纳州是中风、糖尿病、心脏病和癌症等慢性病患病率最高的州之一，所有这些慢性病对非裔美国人的影响都不成比例，他们占全州人口的30%，该州农村社区的40%。因此，我们在开展转化性研究以解决健康差距方面具有得天独厚的优势，这类研究在我们州尤为重要。南卡罗来纳大学拥有强大的机构支持，以及跨学院、单位和部门的协作研究文化，包括我们的附属医院和组织，这加强了我们的研究努力。我们提出了一个为期一年的规划过程，以设计一个临床和转化研究中心(CCTR)，在该中心中，基础科学、临床和转化研究人员与来自医院、社区组织、行业、基于信仰的机构、大学和政府的利益相关者组成团队，开发具体的转化研究项目。我们将围绕特定的内容领域，发展研究组合和基础设施，以促进新知识的传播到床边，然后是社区。作为这一愿景的组成部分，临床和翻译科学家的培训计划将研究设计和传播方面的课程工作与新的CCTR集中的应用经验相结合。一个关键组成部分将是用来衡量业绩标准和最终衡量CCTR有效性的评价方法。这项提议的具体目标是：1)设计一个由四个综合职能部分组成的研究管理核心：行政、方法和信息学、项目和赠款管理以及社区外联。2)设计一个综合计划，以培养临床翻译科学家，包括职业生涯中期的临床医生和临床医生研究人员、“导师学院”、博士后研究员、课程开发、新的翻译研究研究生项目以及本科生的研究经验。3)设计一个虚拟临床转化科学实验室，通过开发一个围绕核心临床研究领域整合研究人员和关键利益相关者的流程。4)设计评估流程以衡量CCTR规划的有效性。我们预计CCTR将在资助期结束时开始作为一个高效的翻译研究中心运行。

DESCRIPTION (provided by applicant): South Carolina ranks among the highest in the prevalence of chronic diseases such as stroke, diabetes, heart disease, and cancer, all of which disproportionately affect African Americans, who comprise 30% of the population statewide, and 40% in the rural communities in this state. Hence, we are uniquely positioned to conduct translational research to address health disparities, and this type of research is particularly important in our State. The University of South Carolina has strong institutional support, a culture of collaborative research across colleges, units, and departments including our affiliated hospitals and organizations that strengthens our research effort. We propose a one-year planning process to design a Center for Clinical and Translational Research (CCTR) in which basic science, clinical, and translational researchers, along with stakeholders from hospitals, community organizations, industry, faith-based institutions, Universities, and government form teams to develop specific translational research programs. We will develop, around specific content areas, research portfolios and infrastructure that facilitate the movement of new knowledge to the bedside and then the community. Integral to this vision is a training program for clinical and translational scientists that combine coursework in research design and dissemination with applied experience centralized within the new CCTR. A critical component will be the evaluation methodology used to measure performance criteria and ultimately, the effectiveness of the CCTR. The Specific Aims of this proposal are: 1) to design a research administration core comprised of four integrated functional components: administrative; methodology and informatics; projects and grants management, and community outreach. 2) To design an integrated program to train clinical translational scientists to include mid-career clinician and clinician researchers, a "College of Mentors", post-doctoral fellows, curricular development, new graduate programs in translational research, and research experiences for undergraduates. 3) To design a virtual clinical translational science laboratory, by developing a process for integrating investigators and key stakeholders around core clinical research areas. 4) To design an evaluation process to measure the effectiveness of CCTR planning. We expect the CCTR to begin operating as an efficient center for translational research, by the end of the funding period.