Established Investigator Award in Cancer Prevention and Control

描述(申请人提供)：K05奖将为托马斯·L·沃恩博士提供保护时间(30%FTE)，以从事与食管腺癌的病因和预防相关的关键研究问题，食管腺癌的发病率在过去30年中增加了6倍以上。它还将提供受保护的时间(20%FTE)，以扩大他在华盛顿大学(UW)和弗雷德·哈钦森癌症研究中心(FHCRC)已经广泛的学生和其他初级调查人员的指导活动。沃恩博士是Barrett‘s和食管腺癌联合会(BEACON)的创始人之一，这是一个由30多名研究人员组成的国际联合会，代表16项研究，部分得到了NCI和NIDDK的支持，并被选为指导委员会的首任主席。该奖项的研究方面将在Beacon的背景下进行，包括：i)继续分析收集的数据和组织，作为Vaughan博士参与的Barrett‘s事件社区病例对照研究的一部分；ii)汇集分析Beacon调查人员进行的多个基于人群的研究的数据；iii)在Beacon内开发新的合作研究项目，利用所代表的不同人群和现有的特征良好的组织银行。沃恩博士在指导研究生和博士后研究员以及流行病学和相关学科的初级教员方面有着良好的记录。他在1990-2006年间担任环境流行病学培训补助金的联席主任；2005年，他担任NCI资助的癌症流行病学和生物统计学培训补助金(T32CA09168)的主任。他经常担任流行病学课程的客座讲师，并曾在23个硕士论文委员会和20个博士论文委员会任职。关于K05的扩展指导活动将包括：i)与他在培训补助金上的职责相关的那些人；ii)他对流行病学和相关部门的其他受训人员以及华盛顿大学和FHCRC公共卫生学科的初级教员的持续指导；以及iii)两名直接从事K05相关研究活动的新的博士后或博士后。

DESCRIPTION (provided by applicant): The K05 award will provide Dr. Thomas L Vaughan with protected time (30% FTE) to pursue key research questions related to the etiology and prevention of esophageal adenocarcinoma, a cancer that has increased over six-fold in incidence over three decades. It will also provide for protected time (20% FTE) to expand his already extensive mentoring activities of students and other junior investigators at the University of Washington (UW) and the Fred Hutchinson Cancer Research Center (FHCRC). Dr. Vaughan was one of the founders of the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON), an international consortium of over 30 investigators representing 16 studies, supported in part by NCI and NIDDK, and was elected as the first Chair of the Steering Committee. The research aspects of this award will be conducted in the context of the BEACON, and consist of: i) continued analyses of data and tissue collected as part of a community-based case-control studies of incident Barrett's for which Dr. Vaughan was PI, ii) pooled analyses of data from multiple population-based studies carried out by BEACON investigators, and iii) development of new collaborative research projects within BEACON that take advantage of the diverse populations represented, and existing banks of well-characterized tissues. Dr. Vaughan has a well-established track record of mentoring graduate students and postdoctoral fellows, as well as junior faculty in Epidemiology and related disciplines. He was Co-director of the Environmental Epidemiology Training Grant from 1990-2006; in 2005 he assumed responsibility as Director of the NCI-funded Cancer Epidemiology and Biostatistics Training Grant (T32CA09168). He is a frequent guest lecturer in established epidemiology courses, and has served on 23 masters thesis committees and 20 doctoral dissertation committees. Expanded mentoring activities on the K05 will include: i) those associated with his responsibilities on the training grant, ii) his ongoing mentoring of other trainees from Epidemiology and related departments, and junior faculty across public health disciplines at the UW and FHCRC, and iii) two new pre- or post-doctoral students working directly on K05-associated research activities.