Social Cognition and Interaction Training for Schizophrenia

描述（由申请人提供）：拟议的项目是一项第三期治疗发展研究，旨在初步评估社会认知与互动（SCIT）计划的有效性。SCIT是一种为期6个月、每周50分钟的团体治疗。56名精神分裂症或分裂情感障碍患者将被随机分配到两种情况中的一种：1)SCIT (n=28)，或2)照常治疗（TAU） （n=28）。所有人都将继续接受常规的医疗护理，包括抗精神病药物。参与者必须符合DSM IV精神分裂症或分裂情感性障碍的标准，不符合物质依赖的现行标准，并且与他人交往有困难。此外，参与者必须年龄在25-60岁之间，男女不限，任何种族背景，智商大于70。参与者将在基线、治疗后（6个月）和完成治疗后6个月对少量明确的结果（由于试点RCT的规模较小）进行评估，包括社会认知、社会功能、生活质量和症状。临床医生对治疗手册的忠实度将通过每周监督、治疗过程录音和保真度量表的使用来评估。偏执狂和神经认知的数据，潜在的调节变量，将在基线收集。利益相关者（来访者和治疗师）只会在治疗后获得反馈，以便告知可能对治疗手册进行的修订。

DESCRIPTION (provided by applicant): The proposed project is a phase 3 treatment development study to conduct a preliminary evaluation of the effectiveness of the Social Cognition and Interaction (SCIT) program. SCIT is a group treatment that is provided in 50-minute weekly sessions over six months. Fifty six individuals with schizophrenia or schizoaffective disorder will be randomly assigned to one of two conditions: 1) SCIT (n=28), or 2) Treatment as usual (TAU) (n=28). All individuals will continue to receive usual medical care for their disorder including antipsychotic medication. Participants must meet DSM IV criteria for schizophrenia or schizoaffective disorder, not meet current criteria for substance dependence, and have difficulty interacting with others. In addition, participants must be between the ages of 25-60, male or female, any ethnic background, and have an IQ greater than 70. Participants will be assessed at baseline, post-treatment (6 months), and 6 months after completing treatment on a small number of well-defined outcomes (due to the small size of the pilot RCT), including social cognition, social functioning, quality of life, and symptoms. Fidelity of clinicians to the treatment manual will be assessed by weekly supervision, audiotaping the therapy sessions, and utilization of fidelity scales. Data on paranoia and neurocognition, potential moderating variables, will be collected at baseline. Stakeholder (client and therapist) feedback will be obtained at post-treatment only, so as to inform possible revisions to the treatment manual.