Serum fatty acids and ischemic stroke in women

描述(申请人提供)：虽然冠心病(CHD)和缺血性中风具有一些共同的主要危险因素，但有限的饮食脂肪和血管疾病风险的流行病学数据表明，脂肪酸与缺血性中风的相关性不同于CHD。脂肪类型和CHD之间已建立的联系似乎不适用于缺血性中风。对这一矛盾观察的一个解释假设是，不同类型的脑动脉中的动脉硬化有不同的原因模式。特别是，动脉粥样硬化可能只涉及大动脉梗塞，而其他危险因素，如血压，可能在卒中的发展中起更重要的作用。然而，关于脂肪酸与缺血性卒中及其亚型(包括腔隙(小动脉)、动脉粥样硬化(大动脉)和心栓性梗塞)之间的关系的数据缺乏。这项研究的总体目标是检查绝经后女性中血清脂肪酸与缺血性中风及其亚型的风险之间的关系。在妇女健康倡议(WHI)观察性研究中，对971例缺血性中风病例和971例匹配对照进行了前瞻性嵌套病例对照研究，以实现这些目标。拟议的项目计划进行两项主要工作：1)利用先前收集和存储的血液样本评估血清脂肪酸组成；2)进行统计分析，承担特定的目标和假设。这项拟议的研究将填补有关脂肪酸与缺血性中风亚型之间关系的知识空白。该项目的发现将潜在地帮助识别缺血性中风的高危人群，并澄清脂肪酸和缺血性中风风险与CHD风险之间的可能差异。这项拟议的研究旨在研究绝经后中风风险增加的女性中，血清脂肪酸与缺血性中风及其亚型的风险之间的关系。这是一个及时和经济的方法来研究绝经后妇女的中风风险。这项研究产生的数据应该为缺血性中风的病因提供新的信息，并为饮食原因的新探索提供数据。公共卫生相关性：这项拟议的研究旨在研究绝经后中风风险增加的女性中，血清脂肪酸与缺血性中风风险及其亚型之间的关系。这是一个及时和经济的方法来研究绝经后妇女的中风风险。这项研究产生的数据应该为缺血性中风的病因提供新的信息，并为饮食原因的新探索提供数据。

DESCRIPTION (provided by applicant): While coronary heart disease (CHD) and ischemic stroke share some major risk factors, limited epidemiological data on dietary fats and vascular disease risk indicate that fatty acids have different associations with ischemic stroke than with CHD. The established associations between types of fat and CHD do not appear to apply to ischemic stroke. One explanatory hypothesis for the paradoxical observations is that arteriosclerosis in different types of cerebral arteries has different causal patterns. Particularly, atherosclerosis may only be involved in large artery infarction, and other risk factors such as blood pressure may play more important role in stroke development However, data on the associations of fatty acids and ischemic stroke and its subtypes including lacunar (small artery), atherosclerotic (large artery) and cardioembolic infarction are lacking. The general goal of this study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women. A prospective nested case-control study of 971 ischemic stroke cases and 971 matched controls in the Women's Health Initiative (WHI) Observational Study is proposed to achieve the objectives. Two major endeavors are planned for the proposed project: 1) assess serum fatty acids composition with previously collected and stored blood specimens; and 2) perform the statistical analyses, which undertake the specific aims and hypothesis. The proposed study will fill the gap in knowledge regarding associations of fatty acids and subtypes of ischemic stroke. Findings from this project will potentially help identify people at high risk of ischemic stroke as well as clarify possible differences between fatty acids and risk of ischemic stroke versus risk of CHD. The proposed study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women who are at increased risk of stroke. It is a timely and economical approach for investigating stroke risk in postmenopausal women. The data generated from this study should provide new information on the etiology of ischemic stroke and data for new explorations of dietary causes. PUBLIC HEALTH RELEVANCE: The proposed study is to examine the associations between serum fatty acids and risk of ischemic stroke and its subtypes among postmenopausal women who are at increased risk of stroke. It is a timely and economical approach for investigating stroke risk in postmenopausal women. The data generated from this study should provide new information on the etiology of ischemic stroke and data for new explorations of dietary causes.