Tissue Perfusion and Blood Flow Monitoring Technology

描述（由申请人提供）：需要能够量化组织灌注，以评估缺血组织（如伤口和皮瓣）的活力。对于糖尿病患者的伤口护理，早期发现血管生成受损是挽救的重要决定因素。这降低了成本，减少了截肢的风险，提高了患者的满意度。大约10%的皮瓣需要修复，修复率约为85%。有效的皮瓣监测将为皮瓣手术提供可能的并发症早期预警，并允许早期干预。目前，主观的目视观察仍普遍用于确定移植物和伤口的改善和评估。基于激光散斑空间分析的成像仪将作为一个独立的单元开发。该方法采用动态事件的空间平均，从一次曝光中获得速度图像的全局图像。从同一场景在不同曝光下获得的图像可以用来提高速度值的精度。它可以实时获取全视野灌注图像。短曝光时间减少了运动伪影的影响。随着美国人口中肥胖的比例越来越高，出现了越来越多的糖尿病病例。提出的激光散斑成像仪为接受高压氧治疗和/或手术的患者提供实时无创组织活力监测。通过确定持续HBO治疗的有效性，它可以减少与皮肤移植翻修相关的医疗人员的财务成本和身体需求。经过临床试验，其商业适销性和应用前景将更加明显。从该项目中获得的科学、技术和临床知识可用于改进高压氧治疗方案，降低治疗成本和时间。根据美国疾病控制与预防中心（Centers for Disease Control and Prevention）的数据，共有2,080万人（占美国人口的7%）患有糖尿病。据估计，2002年美国治疗糖尿病的费用为1,320亿美元，约占医疗保健总支出的11%。该项目旨在开发一种先进的、非接触式、非侵入式光学成像仪，为糖尿病患者选择的伤口区域提供实时、定量的血流速度测量。

DESCRIPTION (provided by applicant): There is a need to be able to quantify tissue perfusion for the purpose of assessing the viability of ischemic tissue such as wounds and flaps. For wound care in diabetes, early detection of angiogenesis compromise is an important determinant of salvage. This reduces cost, reduces risk of amputation, and increases patient satisfaction. Approximately 10% of all flaps require revision with a salvage rate of approximately 85%. Effective monitoring flaps would provide early warning of possible complications for flap surgery and allow earlier intervention. Currently subjective visual observation is still commonly used to identify the improvement and assessment of grafts and wounds. An imager based on the spatial analysis of laser speckle will be developed as a standalone unit. This method employs spatial averaging of the dynamic events to obtain a global picture of the velocity image from one exposure. Images obtained from the same scene at different exposures can be used to improve accuracy of the velocity values. It allows acquisition of full-field perfusion images in real time. The short exposure time reduces the effects of motion artifacts. W with an increasingly high percentage of obesity in the U.S. population, more diabetic cases have emerged. The proposed laser speckle imager provides real-time noninvasive monitoring of tissue viability in patients undergoing hyperbaric oxygen therapy and/or surgery. It can reduce the financial costs and physical demands on the medical staff associated with the revision of skin grafts and by determining the effectiveness of continued HBO treatment. Its commercial marketability and application will become more apparent after the clinical trial. The scientific, technical, and clinical knowledge gained from this project can be utilized to improve protocols for hyperbaric oxygen therapy, reducing both costs and time of treatment. According to the Centers for Disease Control and Prevention, a total of 20.8 million people or 7% of the U.S. population have diabetes. The estimated diabetes cost in the U.S. in 2002 was $132 billion, about 11% of the total health care expenditure. This project is designed to develop an advanced, noncontact, and noninvasive optical imager to provide real-time, quantitative measurements of blood velocities in the selected wound areas of diabetic patients.